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Details on Person I-Smad competes with R-Smad1/5/8 for type I receptor

Class:Id	Reaction:201475
_displayName	I-Smad competes with R-Smad1/5/8 for type I receptor
_doRelease	TRUE
_timestamp	2019-02-07 23:15:24
authored	[InstanceEdit:202631] Huminiecki, L, Moustakas, A, 2007-11-07 10:22:00
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:201460] Jassal, B, 2007-08-13 08:42:05
edited	[InstanceEdit:201460] Jassal, B, 2007-08-13 08:42:05
goBiologicalProcess	[GO_BiologicalProcess:23767] negative regulation of BMP signaling pathway
input	[Complex:201426] BMP:BMPRII:p-4S-BMPRI [plasma membrane] [Homo sapiens] [DefinedSet:173495] I-SMAD [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:178198] Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7 [LiteratureReference:202632] Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads
modified	[InstanceEdit:202635] Jassal, B, 2007-11-07 13:11:04 [InstanceEdit:203121] Jassal, B, 2007-11-12 14:50:39 [InstanceEdit:203414] Jassal, B, 2007-11-13 09:46:28 [InstanceEdit:203536] Jassal, B, 2007-11-14 13:40:00 [InstanceEdit:204116] Jassal, B, 2007-11-26 10:08:02 [InstanceEdit:1832591] Jassal, B, 2011-10-26 [InstanceEdit:2018636] Jassal, Bijay, 2011-11-23 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9635709] D'Eustachio, Peter, 2019-02-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	I-Smad competes with R-Smad1/5/8 for type I receptor
output	[Complex:201446] BMP2:BMP type II receptor:Phospho-BMP type I receptor:I-SMAD [plasma membrane] [Homo sapiens]
releaseDate	2005-09-26
reviewed	[InstanceEdit:203122] Heldin, CH, 2007-11-12
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9635710] Mi, Huaiyu, 2019-02-07
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016454] R-HSA-201475.4
summation	[Summation:201417] I-SMADs reside in the nucleus presumably to be sequestered f...
(hasEvent)	[Pathway:201451] Signaling by BMP [Homo sapiens]
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No pathways have been reviewed or authored by I-Smad competes with R-Smad1/5/8 for type I receptor (201475)