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Details on Person The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus

Class:IdReaction:201472
_displayNameThe phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus
_doReleaseTRUE
_timestamp2016-11-10 00:56:36
authored[InstanceEdit:202631] Huminiecki, L, Moustakas, A, 2007-11-07 10:22:00
compartment[Compartment:13231] nuclear envelope
created[InstanceEdit:201460] Jassal, B, 2007-08-13 08:42:05
input[Complex:201419] p-2S-SMAD1/5/8:SMAD4 [cytosol] [Homo sapiens]
literatureReference[LiteratureReference:178143] An extended bipartite nuclear localization signal in Smad4 is required for its nuclear import and transcriptional activity
[LiteratureReference:202615] Nucleocytoplasmic shuttling of Smad1 conferred by its nuclear localization and nuclear export signals
[LiteratureReference:202637] A novel nuclear export signal in Smad1 is essential for its signaling activity
modified[InstanceEdit:202635] Jassal, B, 2007-11-07 13:11:04
[InstanceEdit:203064] Jassal, B, 2007-11-12 14:34:26
[InstanceEdit:203121] Jassal, B, 2007-11-12 14:50:39
[InstanceEdit:203414] Jassal, B, 2007-11-13 09:46:28
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameThe phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus
output[Complex:201450] p-2S-SMAD1/5/8:SMAD4 [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2005-09-26
reviewed[InstanceEdit:203122] Heldin, CH, 2007-11-12
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358701] R-HSA-201472.3
summation[Summation:201421] The phosphorylated-r-SMAD1/5/8:Co-SMAD complex rapidly trans...
(hasEvent)[Pathway:201451] Signaling by BMP [Homo sapiens]
(precedingEvent)[BlackBoxEvent:201425] Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling [Homo sapiens]
[Reaction:8877941] RUNX2 binds SMAD1 in the nucleus [Homo sapiens]
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