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Details on Person BMP2 binds to the receptor complex

Class:IdReaction:201457
_displayNameBMP2 binds to the receptor complex
_doReleaseTRUE
_timestamp2023-08-21 15:27:28
authored[InstanceEdit:202631] Huminiecki, L, Moustakas, A, 2007-11-07 10:22:00
compartment[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created[InstanceEdit:201460] Jassal, B, 2007-08-13 08:42:05
input[Complex:202640] BMPRII:BMPRI [plasma membrane] [Homo sapiens]
[Complex:201463] BMP2 dimer [extracellular region] [Homo sapiens]
internalReviewed[InstanceEdit:9842177] Orlic-Milacic, Marija, 2023-08-21
literatureReference[LiteratureReference:202608] Cloning and characterization of a human type II receptor for bone morphogenetic proteins
modified[InstanceEdit:202635] Jassal, B, 2007-11-07 13:11:04
[InstanceEdit:203121] Jassal, B, 2007-11-12 14:50:39
[InstanceEdit:203414] Jassal, B, 2007-11-13 09:46:28
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:8984961] Duenas, Corina, 2017-04-11
[InstanceEdit:9635709] D'Eustachio, Peter, 2019-02-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9839333] Tiwari, Krishna, 2023-07-05
[InstanceEdit:9840927] Tiwari, Krishna, 2023-08-01
[InstanceEdit:9842179] Orlic-Milacic, Marija, 2023-08-21
nameBMP2 binds to the receptor complex
output[Complex:201459] BMP:BMPRII:BMPRI [plasma membrane] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821384] two stars
regulatedBy[NegativeRegulation:9839345] Negative regulation by 'INHIBIN-A:TGFBR3:ACVR2A [plasma membrane]'
regulationReference[RegulationReference:9840924] Negative regulation by 'InhibinA:TGFBR3:ACVR2A' Inhibin is an antagonist of bone morphogenetic protein signaling
releaseDate2005-09-26
reviewed[InstanceEdit:203122] Heldin, CH, 2007-11-12
reviewStatus[ReviewStatus:9821385] four stars
revised[InstanceEdit:9635710] Mi, Huaiyu, 2019-02-07
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358280] R-HSA-201457.6
structureModified[InstanceEdit:9839333] Tiwari, Krishna, 2023-07-05
summation[Summation:201420] The mature dimeric BMP2 binds with high affinity to its sign...
(hasEvent)[Pathway:201451] Signaling by BMP [Homo sapiens]
(precedingEvent)[Reaction:201443] Type II receptor phosphorylates type I receptor [Homo sapiens]
(updatedInstance)[_UpdateTracker:9778497] Update Tracker - [Reaction:201457] BMP2 binds to the receptor complex - v68:[removeCatalystActivity]
[_UpdateTracker:9781499] Update Tracker - [Reaction:201457] BMP2 binds to the receptor complex - v61:[addLiteratureReference, modifyText]
[_UpdateTracker:9842251] Update Tracker - [Reaction:201457] BMP2 binds to the receptor complex - v86:[addRegulator, modifyText]
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