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Details on Person Formation of the hetero-tetrameric BMP2:receptor complex ind...

Class:IdSummation:201449
_displayNameFormation of the hetero-tetrameric BMP2:receptor complex ind...
_timestamp2007-11-12 14:34:49
created[InstanceEdit:201460] Jassal, B, 2007-08-13 08:42:05
modified[InstanceEdit:203064] Jassal, B, 2007-11-12 14:34:26
textFormation of the hetero-tetrameric BMP2:receptor complex induces receptor rotation, so that their cytoplasmic kinase domains face each other in a catalytically favourable configuration. The constitutively active type II receptor kinase (which auto-phosphorylates in the absence of ligand), trans-phosphorylates specific serine residues at the conserved Gly-Ser-rich juxtapositioned domain of the type I receptor. It is not known if exactly 8 ATPs are required for the phosphorylation of type I receptor, there could be more or less than this number.
(summation)[Reaction:201443] Type II receptor phosphorylates type I receptor [Homo sapiens]
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