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Details on Person Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8

Class:Id	BlackBoxEvent:201445
_displayName	Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8
_doRelease	TRUE
_timestamp	2019-02-07 23:15:27
authored	[InstanceEdit:202631] Huminiecki, L, Moustakas, A, 2007-11-07 10:22:00
catalystActivity	[CatalystActivity:173534] ubiquitin protein ligase activity of SMURF [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:201460] Jassal, B, 2007-08-13 08:42:05
goBiologicalProcess	[GO_BiologicalProcess:23767] negative regulation of BMP signaling pathway
input	[DefinedSet:201424] SMAD1/5/8 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:175938] Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase [LiteratureReference:202636] A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation [LiteratureReference:202618] Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling
modified	[InstanceEdit:201562] Jassal, B, 2007-09-03 08:15:34 [InstanceEdit:202635] Jassal, B, 2007-11-07 13:11:04 [InstanceEdit:203121] Jassal, B, 2007-11-12 14:50:39 [InstanceEdit:203414] Jassal, B, 2007-11-13 09:46:28 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9635709] D'Eustachio, Peter, 2019-02-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8
releaseDate	2005-09-26
reviewed	[InstanceEdit:203122] Heldin, CH, 2007-11-12
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9635710] Mi, Huaiyu, 2019-02-07
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361691] R-HSA-201445.4
summation	[Summation:176009] SMAD2 is polyubiquitinated by SMURF2 and targeted for protea...
(hasEvent)	[Pathway:201451] Signaling by BMP [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9788609] Update Tracker - [BlackBoxEvent:201445] Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 - v41:[modifyText] [_UpdateTracker:9789145] Update Tracker - [BlackBoxEvent:201445] Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 - v38:[modifyText]
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