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Details on Person Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling

Class:Id	BlackBoxEvent:201425
_displayName	Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling
_doRelease	TRUE
_timestamp	2019-02-07 23:15:29
authored	[InstanceEdit:202631] Huminiecki, L, Moustakas, A, 2007-11-07 10:22:00
catalystActivity	[CatalystActivity:173531] ubiquitin-protein transferase activity of Nuclear ubiquitin ligase [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:201460] Jassal, B, 2007-08-13 08:42:05
goBiologicalProcess	[GO_BiologicalProcess:23767] negative regulation of BMP signaling pathway
input	[Complex:201450] p-2S-SMAD1/5/8:SMAD4 [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:173532] SMAD destruction turns off signalling [LiteratureReference:202601] Proteasomal degradation of Smad1 induced by bone morphogenetic proteins
modified	[InstanceEdit:202635] Jassal, B, 2007-11-07 13:11:04 [InstanceEdit:203121] Jassal, B, 2007-11-12 14:50:39 [InstanceEdit:203410] Jassal, B, 2007-11-13 09:15:53 [InstanceEdit:203414] Jassal, B, 2007-11-13 09:46:28 [InstanceEdit:2671734] D'Eustachio, P, 2012-11-23 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9635709] D'Eustachio, Peter, 2019-02-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling
precedingEvent	[Reaction:201472] The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus [Homo sapiens] [Reaction:201422] Phospho-R-Smad1/5/8 forms a complex with Co-Smad [Homo sapiens]
releaseDate	2005-09-26
reviewed	[InstanceEdit:203122] Heldin, CH, 2007-11-12
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9635710] Mi, Huaiyu, 2019-02-07
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359344] R-HSA-201425.4
summation	[Summation:176007] The nuclear R-SMAD:Co-SMAD complex recruits ubiquitin conjug...
(hasEvent)	[Pathway:201451] Signaling by BMP [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9788557] Update Tracker - [BlackBoxEvent:201425] Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling - v41:[modifyText] [_UpdateTracker:9789272] Update Tracker - [BlackBoxEvent:201425] Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling - v38:[modifyText]
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