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Details on Person The mature dimeric BMP2 binds with high affinity to its sign...
| Class:Id | Summation:201420 |
|---|---|
| _displayName | The mature dimeric BMP2 binds with high affinity to its sign... |
| _timestamp | 2023-08-21 15:26:57 |
| created | [InstanceEdit:201460] Jassal, B, 2007-08-13 08:42:05 |
| literatureReference | [LiteratureReference:202608] Cloning and characterization of a human type II receptor for bone morphogenetic proteins [LiteratureReference:9840171] Inhibin is an antagonist of bone morphogenetic protein signaling |
| modified | [InstanceEdit:8984961] Duenas, Corina, 2017-04-11 [InstanceEdit:9842163] Tiwari, Krishna, 2023-08-21 [InstanceEdit:9842177] Orlic-Milacic, Marija, 2023-08-21 |
| text | The mature dimeric BMP2 binds with high affinity to its signalling receptor, the type II receptor serine/threonine kinase. The type II receptor is known to form dimeric complexes even in the absence of BMP2 (Rosenzweig et al.1995). Also, TGFBR3 (Betaglycan) antagonises BMP2 signalling by binding with ACVR2A (ActRII). TGFBR3 and BMP2 compete for ACVR2A and TGFBR3 thus inhibits BMP2 signalling (Waiter et al. 2003). |
| (summation) | [Reaction:201457] BMP2 binds to the receptor complex [Homo sapiens] |
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No pathways have been reviewed or authored by The mature dimeric BMP2 binds with high affinity to its sign... (201420)
