Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
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Details on Person I-SMADs reside in the nucleus presumably to be sequestered f...
| Class:Id | Summation:201417 |
|---|---|
| _displayName | I-SMADs reside in the nucleus presumably to be sequestered f... |
| _timestamp | 2007-08-13 08:42:32 |
| created | [InstanceEdit:201460] Jassal, B, 2007-08-13 08:42:05 |
| text | I-SMADs reside in the nucleus presumably to be sequestered from the BMP2:receptor complex and thus avoid inappropriate silencing of the signalling pathway. Upon activation of the signalling pathway, I-SMADs exit the nucleus and are recruited to the signalling BMP2:receptor complex. I-SMADs directly bind to the so-called L45 loop of the type I receptor, the site of binding of R-SMADs. Thus, I-SMADs competitively inhibit the activation/phosphorylation of R-SMADs. |
| (summation) | [Reaction:201475] I-Smad competes with R-Smad1/5/8 for type I receptor [Homo sapiens] |
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No pathways have been reviewed or authored by I-SMADs reside in the nucleus presumably to be sequestered f... (201417)
