Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Botulinum toxin type D light chain (botD LC), in the cytosol...
| Class:Id | Summation:201315 |
|---|---|
| _displayName | Botulinum toxin type D light chain (botD LC), in the cytosol... |
| _timestamp | 2020-10-08 21:59:57 |
| created | [InstanceEdit:201316] Gopinathrao, G, 2007-08-03 18:19:30 |
| modified | [InstanceEdit:5263577] D'Eustachio, Peter, 2014-02-11 [InstanceEdit:5602263] D'Eustachio, Peter, 2014-06-20 [InstanceEdit:9704403] D'Eustachio, Peter, 2020-10-08 |
| text | Botulinum toxin type D light chain (botD LC), in the cytosol of a target cell, catalyzes the removal of an aminoterminal peptide from vesicle-associated membrane protein 1 (VAMP1). botD LC is a zinc metalloprotease (Arndt et al. 2006; Schiavo et al. 1993; Yamasaki et al. 1994). VAMP1 is associated with the cytosolic face of the target cell synaptic vesicle and is required for vesicle docking and exocytosis. Its cleavage by botulinum toxin blocks synaptic vesicle fusion with the plasma membrane and neurotransmitter release (Sudhof et al, 1993; Sudhof 2004). |
| (summation) | [Reaction:194809] botD LC cleaves target cell VAMP1 [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by Botulinum toxin type D light chain (botD LC), in the cytosol... (201315)
