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Details on Person Botulinum toxin type B light chain (botB LC), in the cytosol...
| Class:Id | Summation:201309 |
|---|---|
| _displayName | Botulinum toxin type B light chain (botB LC), in the cytosol... |
| _timestamp | 2020-10-08 21:59:57 |
| created | [InstanceEdit:201316] Gopinathrao, G, 2007-08-03 18:19:30 |
| modified | [InstanceEdit:5263577] D'Eustachio, Peter, 2014-02-11 [InstanceEdit:5602263] D'Eustachio, Peter, 2014-06-20 [InstanceEdit:9704403] D'Eustachio, Peter, 2020-10-08 |
| text | Botulinum toxin type B light chain (botB LC), in the cytosol of a target cell, catalyzes the removal of an aminoterminal peptide from vesicle-associated membrane protein 2 (VAMP2). botB LC is a zinc metalloprotease (Foran et al. 1994; Schiavo et al. 1992). VAMP2 is associated with the cytosolic face of the target cell synaptic vesicle and is required for vesicle docking and exocytosis. Its cleavage by botulinum toxin blocks synaptic vesicle fusion with the plasma membrane and neurotransmitter release and in vivo leads to a long lasting flaccid paralysis (Sudhof et al, 1993; Sudhof 2004). |
| (summation) | [Reaction:194796] botB LC cleaves target cell VAMP2 [Homo sapiens] |
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No pathways have been reviewed or authored by Botulinum toxin type B light chain (botB LC), in the cytosol... (201309)
