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Details on Person Autocatalytic phosphorylation of FGFR3c P250R mutant
Class:Id Reaction:2012073 _displayName Autocatalytic phosphorylation of FGFR3c P250R mutant _doRelease TRUE _timestamp 2015-05-07 19:54:25 authored [InstanceEdit:2105031] Rothfels, K, 2012-02-09 catalystActivity [CatalystActivity:2012066] protein tyrosine kinase activity of FGFR3c P250R mutant dimer bound to FGF [plasma membrane] compartment [Compartment:876] plasma membrane [Compartment:70101] cytosol created [InstanceEdit:2012075] Rothfels, K, 2011-11-22 disease [Disease:2011822] acrocephalosyndactylia [Disease:2011847] craniosynostosis [Disease:2032940] bone development disease edited [InstanceEdit:2252592] Rothfels, K, 2012-05-16 entityFunctionalStatus [EntityFunctionalStatus:5654464] gain_of_function of FGFR3c P250R mutant dimer bound to FGF [plasma membrane] input [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:2011952] FGFR3c P250R mutant dimer bound to FGF [plasma membrane] [Homo sapiens] isChimeric FALSE literatureReference [LiteratureReference:2011820] Proline to arginine mutations in FGF receptors 1 and 3 result in Pfeiffer and Muenke craniosynostosis syndromes through enhancement of FGF binding affinity modified [InstanceEdit:2033505] Rothfels, K, 2012-01-09 [InstanceEdit:2064282] Rothfels, K, 2012-01-18 [InstanceEdit:2065185] Rothfels, K, 2012-01-20 [InstanceEdit:2105599] Rothfels, K, 2012-02-10 [InstanceEdit:2105675] Rothfels, K, 2012-02-10 [InstanceEdit:2123529] Rothfels, K, 2012-02-14 [InstanceEdit:2156368] Rothfels, K, 2012-02-28 [InstanceEdit:2248846] Rothfels, K, 2012-05-15 [InstanceEdit:2275109] Rothfels, K, 2012-05-25 [InstanceEdit:5654465] Rothfels, Karen, 2014-12-03 [InstanceEdit:5691461] Rothfels, Karen, 2015-05-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name Autocatalytic phosphorylation of FGFR3c P250R mutant output [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:2011989] Activated FGFR3c P250R mutant [plasma membrane] [Homo sapiens] precedingEvent
releaseDate 2012-06-12 reviewed [InstanceEdit:2248845] Ezzat, S, 2012-05-15 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:2294932] R-HSA-2012073.2 summation [Summation:2064283] After high-affinity ligand binding, FGFR3 P250R is believed ... (hasEvent) [Pathway:1839130] Signaling by activated point mutants of FGFR3 [Homo sapiens]
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