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Details on Person p-8Y-FGFR2c P253R [plasma membrane]

Class:Id	EntityWithAccessionedSequence:2011880
_displayName	p-8Y-FGFR2c P253R [plasma membrane]
_timestamp	2014-11-20 17:34:56
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2011881] Rothfels, K, 2011-11-22
disease	[Disease:1614674] female reproductive endometrioid cancer [Disease:2011822] acrocephalosyndactylia
endCoordinate	821
hasModifiedResidue	[ReplacedResidue:1637915] L-proline 253 replaced with L-arginine [ModifiedResidue:1307864] O4'-phospho-L-tyrosine at 466 [ModifiedResidue:1307872] O4'-phospho-L-tyrosine at 586 [ModifiedResidue:1307873] O4'-phospho-L-tyrosine at 588 [ModifiedResidue:1307882] O4'-phospho-L-tyrosine at 656 [ModifiedResidue:1307883] O4'-phospho-L-tyrosine at 657 [ModifiedResidue:1307889] O4'-phospho-L-tyrosine at 733 [ModifiedResidue:1307900] O4'-phospho-L-tyrosine at 769 [ModifiedResidue:1307907] O4'-phospho-L-tyrosine at 779
literatureReference	[LiteratureReference:1637882] Drug-sensitive FGFR2 mutations in endometrial carcinoma [LiteratureReference:1637876] Apert syndrome results from localized mutations of FGFR2 and is allelic with Crouzon syndrome [LiteratureReference:2011820] Proline to arginine mutations in FGF receptors 1 and 3 result in Pfeiffer and Muenke craniosynostosis syndromes through enhancement of FGF binding affinity
modified	[InstanceEdit:2029887] Rothfels, K, 2012-01-05 [InstanceEdit:2071964] Rothfels, K, 2012-01-26 [InstanceEdit:3612887] Jupe, S, 2013-05-23 [InstanceEdit:3622479] Rothfels, K, 2013-05-24 [InstanceEdit:5649622] Rothfels, Karen, 2014-11-20
name	p-8Y-FGFR2c P253R p-8Y-FGFR2-1 P253R
referenceEntity	[ReferenceIsoform:54816] UniProt:P21802-1 FGFR2 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2295864] R-HSA-2011880.1
startCoordinate	22
summation	[Summation:1637914] also Apert
(hasComponent)	[Complex:2011967] p-8Y-FGFR2c P253R dimer [plasma membrane] [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9883298] Update Tracker - [EntityWithAccessionedSequence:2011880] p-8Y-FGFR2c P253R [plasma membrane] - v45:[addName] [_UpdateTracker:9891581] Update Tracker - [EntityWithAccessionedSequence:2011880] p-8Y-FGFR2c P253R [plasma membrane] - v52:[modifyName]
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No pathways have been reviewed or authored by p-8Y-FGFR2c P253R [plasma membrane] (2011880)