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Details on Person p-8Y-FGFR1c P252T [plasma membrane]

Class:Id	EntityWithAccessionedSequence:2011868
_displayName	p-8Y-FGFR1c P252T [plasma membrane]
_timestamp	2018-01-26 17:21:28
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2011869] Rothfels, K, 2011-11-22
disease	[Disease:1500699] lung cancer
endCoordinate	822
hasModifiedResidue	[ReplacedResidue:1614384] L-proline 252 replaced with L-threonine [ModifiedResidue:2011867] O4'-phospho-L-tyrosine at 463 [ModifiedResidue:2011863] O4'-phospho-L-tyrosine at 583 [ModifiedResidue:2011864] O4'-phospho-L-tyrosine at 585 [ModifiedResidue:2011862] O4'-phospho-L-tyrosine at 653 [ModifiedResidue:2011865] O4'-phospho-L-tyrosine at 654 [ModifiedResidue:2011860] O4'-phospho-L-tyrosine at 730 [ModifiedResidue:1838976] O4'-phospho-L-tyrosine at 766 [ModifiedResidue:2011859] O4'-phospho-L-tyrosine at 776
inferredFrom	[EntityWithAccessionedSequence:2011858] p-8Y-FGFR1c P252R [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:1614272] Somatic mutations of the protein kinase gene family in human lung cancer [LiteratureReference:1614274] Targeting mutant fibroblast growth factor receptors in cancer
modified	[InstanceEdit:2023375] Rothfels, K, 2011-12-07 [InstanceEdit:2066021] Rothfels, K, 2012-01-25 [InstanceEdit:2565931] Jassal, B, 2012-11-08 [InstanceEdit:5649605] Rothfels, Karen, 2014-11-20 [InstanceEdit:9036004] Rothfels, Karen, 2018-01-26
name	p-8Y-FGFR1c P252T
referenceEntity	[ReferenceIsoform:54814] UniProt:P11362-1 FGFR1 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2297190] R-HSA-2011868.2
startCoordinate	22
summation	[Summation:1614382] thought to increase # hydrogen bonds, increase ligand affini...
(hasComponent)	[Complex:2018773] p-8Y-FGFR1c P252T dimer [plasma membrane] [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9873868] Update Tracker - [EntityWithAccessionedSequence:2011868] p-8Y-FGFR1c P252T [plasma membrane] - v43:[modifyName] [_UpdateTracker:9892075] Update Tracker - [EntityWithAccessionedSequence:2011868] p-8Y-FGFR1c P252T [plasma membrane] - v52:[modifyName] [_UpdateTracker:9898594] Update Tracker - [EntityWithAccessionedSequence:2011868] p-8Y-FGFR1c P252T [plasma membrane] - v64:[add_removeReferenceEntity, modifyName]
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No pathways have been reviewed or authored by p-8Y-FGFR1c P252T [plasma membrane] (2011868)