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Details on Person ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA

Class:Id	Reaction:201035
_displayName	ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA
_doRelease	TRUE
_timestamp	2016-11-10 00:57:06
authored	[InstanceEdit:201063] Gopinathrao, G, 2007-07-29 21:03:03
catalystActivity	[CatalystActivity:200992] long-chain fatty acid-CoA ligase activity of ACSL1,3,5,6 [endoplasmic reticulum membrane]
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:201001] Gopinathrao, G, 2007-07-29 16:52:53
edited	[InstanceEdit:5678222] D'Eustachio, Peter, 2015-02-21
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:76194] CoA-SH [cytosol] [SimpleEntity:3632881] PALM [cytosol]
literatureReference	[LiteratureReference:201003] Identification and molecular characterization of acyl-CoA synthetase in human erythrocytes and erythroid precursors [LiteratureReference:548673] Involvement of ACSL in local synthesis of neutral lipids in cytoplasmic lipid droplets in human hepatocyte HuH7 [LiteratureReference:548752] Regulation of enterocyte apoptosis by acyl-CoA synthetase 5 splicing
modified	[InstanceEdit:201062] Gopinathrao, G, 2007-07-29 16:59:33 [InstanceEdit:201085] Gopinathrao, G, 2007-07-30 15:43:15 [InstanceEdit:201092] Gopinathrao, G, 2007-07-31 11:22:43 [InstanceEdit:201317] Gopinathrao, G, 2007-08-03 18:51:55 [InstanceEdit:539124] D'Eustachio, P, 2010-03-09 [InstanceEdit:548837] D'Eustachio, P, 2010-03-14 [InstanceEdit:548845] D'Eustachio, P, 2010-03-14 [InstanceEdit:5676071] Jassal, Bijay, 2015-02-19 [InstanceEdit:5676159] Jassal, Bijay, 2015-02-19 [InstanceEdit:5676161] Jassal, Bijay, 2015-02-19 [InstanceEdit:5676162] Jassal, Bijay, 2015-02-19 [InstanceEdit:5678221] D'Eustachio, Peter, 2015-02-21 [InstanceEdit:5678227] D'Eustachio, Peter, 2015-02-21 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O Conversion of palmitic acid to palmitoyl-CoA
output	[SimpleEntity:76577] AMP [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:200993] PALM-CoA [cytosol] [SimpleEntity:111294] PPi [cytosol]
releaseDate	2007-09-04
reviewed	[InstanceEdit:5678222] D'Eustachio, Peter, 2015-02-21
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:548846] D'Eustachio, P, 2010-03-14 [InstanceEdit:5676160] Jassal, Bijay, 2015-02-19
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358872] R-HSA-201035.3
summation	[Summation:201086] Membrane-associated acyl-CoA synthetase long-chain family me...
(hasEvent)	[Pathway:75876] Synthesis of very long-chain fatty acyl-CoAs [Homo sapiens]
(precedingEvent)	[Reaction:548814] ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA [Homo sapiens]
(replacementInstances)	[_Deleted:5676219] Deletion of instances: 548792, 164987, 75880
(updatedInstance)	[_UpdateTracker:9785256] Update Tracker - [Reaction:201035] ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA - v52:[addLiteratureReference, add_removeInput, modifyText] [_UpdateTracker:9790518] Update Tracker - [Reaction:201035] ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA - v33:[addInput, addOutput, modifyText]
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