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Details on Person Nef Binds and activates the Src-family tyrosine kinase Lck

Class:Id	Reaction:200954
_displayName	Nef Binds and activates the Src-family tyrosine kinase Lck
_doRelease	TRUE
_timestamp	2016-11-10 00:54:51
authored	[InstanceEdit:200905] Gillespie, ME, 2007-07-25 19:42:36
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:200953] Gillespie, ME, 2007-07-26 04:51:49
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
input	[EntityWithAccessionedSequence:167605] myristoylated nef [cytosol] [Human immunodeficiency virus 1] [EntityWithAccessionedSequence:167609] LCK [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:200833] Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4 [LiteratureReference:200936] The conserved core of human immunodeficiency virus type 1 Nef is essential for association with Lck and for enhanced viral replication in T-lymphocytes
modified	[InstanceEdit:201389] Gillespie, ME, 2007-08-07 14:42:02 [InstanceEdit:3076315] Gillespie, ME, 2013-02-06 [InstanceEdit:5621512] Matthews, Lisa, 2014-08-29 [InstanceEdit:5656435] Gillespie, Marc E, 2014-12-12 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Nef Binds and activates the Src-family tyrosine kinase Lck
output	[Complex:200922] Lck:Nef [cytosol] [Homo sapiens]
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2005-09-26
reviewed	[InstanceEdit:201388] Skowronski, J, 2007-08-07 14:33:41
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358401] R-HSA-200954.3
summation	[Summation:200933] The Nef protein of the primate lentiviruses, including human...
(hasEvent)	[Pathway:164944] Nef and signal transduction [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9787564] Update Tracker - [Reaction:200954] Nef Binds and activates the Src-family tyrosine kinase Lck - v44:[add_removeInput]
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