Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person The Nef protein of the primate lentiviruses, including human...
| Class:Id | Summation:200933 |
|---|---|
| _displayName | The Nef protein of the primate lentiviruses, including human... |
| _timestamp | 2007-07-26 04:51:55 |
| created | [InstanceEdit:200953] Gillespie, ME, 2007-07-26 04:51:49 |
| literatureReference | [LiteratureReference:200936] The conserved core of human immunodeficiency virus type 1 Nef is essential for association with Lck and for enhanced viral replication in T-lymphocytes |
| text | The Nef protein of the primate lentiviruses, including human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV), is a myristylated protein associated with increased viral replication and enhanced pathogenicity. Both the potentiation of T-lymphocyte activation and the enhanced serine-phosphorylation of HIV-1 capsid by Nef correlate with increased viral replication. The Nef proteins from HIV-1 and SIV bind to Lck. The SH3 and SH2 domains of Lck are sufficient for coprecipitation with non-tyrosine-phosphorylated Nef proteins. The conserved core region of HIV-1 Nef is essential for the interaction with Lck and is also important for enhanced HIV-1 replication in T-lymphocytes. The SIV and HIV-1 Nef proteins are differentially tyrosine-phosphorylated. The kinase-active Lck tyrosine-phosphorylates SIVmac239 Nef but does not phosphorylate HIV-1 Nef. |
| (summation) | [Reaction:200954] Nef Binds and activates the Src-family tyrosine kinase Lck [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by The Nef protein of the primate lentiviruses, including human... (200933)
