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Details on Person Cytosolic folylpolyglutamate synthase catalyzes the reaction...
| Class:Id | Summation:200744 |
|---|---|
| _displayName | Cytosolic folylpolyglutamate synthase catalyzes the reaction... |
| _timestamp | 2007-07-23 20:23:19 |
| created | [InstanceEdit:200727] D'Eustachio, P, 2007-07-23 20:23:04 |
| text | Cytosolic folylpolyglutamate synthase catalyzes the reaction of 5-methylTHF-glutamate(n), L-glutamate, and ATP to form 5-methylTHF-glutamate(n+1), ADP, and orthophosphate. (The first glutamate residue is attached to the glutamate moiety of 5-methylTHF itself; for convenience the process is annotated here as if it proceeded in a single concerted step.) The extent of conjugation is variable, but the commonest cytosolic form of 5-methylTHF has five added glutamate residues. Although its properties as a donor of one-carbon units are not affected by glutamate addition, 5-methylTHF that lacks added glutamate residues cannot be retained in the cytosol so this reaction is needed for normal 5-methylTHF function under physiological conditions (Garrow et al. 1992; Chen et al. 1996). |
| (summation) | [Reaction:200681] FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG [Homo sapiens] |
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