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Details on Person 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate

Class:Id	Reaction:200740
_displayName	5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate
_doRelease	TRUE
_timestamp	2010-05-12 19:06:55
catalystActivity	[CatalystActivity:200745] methenyltetrahydrofolate cyclohydrolase activity of MTHFD1 dimer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:200727] D'Eustachio, P, 2007-07-23 20:23:04
input	[SimpleEntity:200640] 5,10-methenyl-THFPG [cytosol] [SimpleEntity:29356] H2O [cytosol]
literatureReference	[LiteratureReference:200643] C1-Tetrahydrofolate synthase from rabbit liver. Structural and kinetic properties of the enzyme and its two domains. [LiteratureReference:200726] Primary structure of a human trifunctional enzyme. Isolation of a cDNA encoding methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase.
modified	[InstanceEdit:200987] Gopinathrao, G, 2007-07-27 15:28:23 [InstanceEdit:201089] D'Eustachio, P, 2007-07-30 19:05:06 [InstanceEdit:201332] Gopinathrao, G, 2007-08-06 14:46:29 [InstanceEdit:732460] D'Eustachio, P, 2010-05-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate
output	[SimpleEntity:111353] 10-formyl-THFPG [cytosol]
precedingEvent	[Reaction:200644] 5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ [Homo sapiens]
releaseDate	2007-08-21
reverseReaction	[Reaction:200661] MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG [Homo sapiens] [Reaction:200740] 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate [Homo sapiens]
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361631] R-HSA-200740.2
summation	[Summation:200707] The methenyltetrahydrofolate cyclohydrolase activity of the ...
(hasEvent)	[Pathway:196757] Metabolism of folate and pterines [Homo sapiens]
(precedingEvent)	[Reaction:6808496] ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG [Homo sapiens]
(reverseReaction)	[Reaction:200661] MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG [Homo sapiens]
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No pathways have been reviewed or authored by 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (200740)