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Details on Person FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG

Class:Id	Reaction:200681
_displayName	FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG
_doRelease	TRUE
_timestamp	2020-12-10 13:55:15
catalystActivity	[CatalystActivity:197957] tetrahydrofolylpolyglutamate synthase activity of FPGS-2 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:200727] D'Eustachio, P, 2007-07-23 20:23:04
input	[SimpleEntity:200665] 5-methyl-THF [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:29404] L-Glu [cytosol] [SimpleEntity:29404] L-Glu [cytosol] [SimpleEntity:29404] L-Glu [cytosol] [SimpleEntity:29404] L-Glu [cytosol] [SimpleEntity:29404] L-Glu [cytosol]
literatureReference	[LiteratureReference:197962] Expression cloning of a human cDNA encoding folylpoly(gamma-glutamate) synthetase and determination of its primary structure [LiteratureReference:200690] Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene
modified	[InstanceEdit:200987] Gopinathrao, G, 2007-07-27 15:28:23 [InstanceEdit:201332] Gopinathrao, G, 2007-08-06 14:46:29 [InstanceEdit:732460] D'Eustachio, P, 2010-05-12 [InstanceEdit:9709130] Jassal, Bijay, 2020-12-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate
output	[SimpleEntity:174404] 5-methyl-THFPG [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[Reaction:200652] SLC19A1 transports 5-methyl-THF from extracellular region to cytosol [Homo sapiens]
releaseDate	2007-08-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360501] R-HSA-200681.3
summation	[Summation:200744] Cytosolic folylpolyglutamate synthase catalyzes the reaction...
(hasEvent)	[Pathway:196757] Metabolism of folate and pterines [Homo sapiens]
(precedingEvent)	[Reaction:174374] MTR transfers CH3 from MeCbl to HCYS [Homo sapiens]
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