Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG

Class:Id	Reaction:200676
_displayName	MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG
_doRelease	TRUE
_timestamp	2020-12-10 13:55:53
catalystActivity	[CatalystActivity:200678] methylenetetrahydrofolate reductase [NAD(P)H] activity of MTHFR dimer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:200727] D'Eustachio, P, 2007-07-23 20:23:04
input	[SimpleEntity:200739] 5,10-methylene-THFPG [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:70106] H+ [cytosol]
literatureReference	[LiteratureReference:200714] Seven novel mutations in the methylenetetrahydrofolate reductase gene and genotype/phenotype correlations in severe methylenetetrahydrofolate reductase deficiency
modified	[InstanceEdit:200987] Gopinathrao, G, 2007-07-27 15:28:23 [InstanceEdit:201332] Gopinathrao, G, 2007-08-06 14:46:29 [InstanceEdit:732460] D'Eustachio, P, 2010-05-12 [InstanceEdit:9709130] Jassal, Bijay, 2020-12-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG 5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+
output	[SimpleEntity:174404] 5-methyl-THFPG [cytosol] [SimpleEntity:29366] NADP+ [cytosol]
precedingEvent	[Reaction:200718] MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG [Homo sapiens] [Reaction:200661] MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG [Homo sapiens] [Reaction:200735] SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG [Homo sapiens] [Reaction:197958] FPGS-2 transforms THF to THFPG [Homo sapiens] [Reaction:6808496] ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG [Homo sapiens]
releaseDate	2007-08-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360076] R-HSA-200676.3
summation	[Summation:200725] Cytosolic MTHFR dimer catalyzes the reaction of 5,10-methyle...
(hasEvent)	[Pathway:196757] Metabolism of folate and pterines [Homo sapiens]
(precedingEvent)	[Reaction:174374] MTR transfers CH3 from MeCbl to HCYS [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (200676)