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Details on Person The methylenetetrahydrofolate dehydrogenase activity of the ...
| Class:Id | Summation:200653 |
|---|---|
| _displayName | The methylenetetrahydrofolate dehydrogenase activity of the ... |
| _timestamp | 2007-07-30 19:06:14 |
| created | [InstanceEdit:200727] D'Eustachio, P, 2007-07-23 20:23:04 |
| modified | [InstanceEdit:201090] D'Eustachio, P, 2007-07-30 19:06:17 |
| text | The methylenetetrahydrofolate dehydrogenase activity of the trifunctional MTHFD1 enzyme catalyzes the reversible reaction of 5,10-methyleneTHF polyglutamate and NADP+ to form 5,10-methenylTHF polyglutamate, NADPH, and H+. MTHFD1 is cytosolic and occurs as a dimer. The human enzyme has been identified and partially characterized biochemically (Hum et al. 1988); additional reaction details can be inferred from the properties of the well-studied homologous rabbit enzyme (Villar et al. 1985). |
| (summation) | [Reaction:200644] 5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ [Homo sapiens] |
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No pathways have been reviewed or authored by The methylenetetrahydrofolate dehydrogenase activity of the ... (200653)
