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Details on Person Cytosolic folate export across the plasma membrane

Class:Id	Reaction:200646
_displayName	Cytosolic folate export across the plasma membrane
_doRelease	TRUE
_timestamp	2024-11-19 23:30:52
catalystActivity	[CatalystActivity:200706] folic acid:proton symporter activity of SLC46A1 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9928938] folic acid:proton symporter activity of SLC46A1 [plasma membrane] Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:200727] D'Eustachio, P, 2007-07-23 20:23:04
input	[SimpleEntity:197965] FOLA [cytosol] [SimpleEntity:70106] H+ [cytosol]
internalReviewed	[InstanceEdit:9928941] D'Eustachio, Peter, 2024-11-18
literatureReference	[LiteratureReference:200690] Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene [LiteratureReference:200704] Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption [LiteratureReference:9928933] Cloning and functional characterization of the proton-coupled electrogenic folate transporter and analysis of its expression in retinal cell types
modified	[InstanceEdit:200987] Gopinathrao, G, 2007-07-27 15:28:23 [InstanceEdit:201332] Gopinathrao, G, 2007-08-06 14:46:29 [InstanceEdit:732460] D'Eustachio, P, 2010-05-12 [InstanceEdit:8942346] Jassal, Bijay, 2016-10-13 [InstanceEdit:9005902] D'Eustachio, Peter, 2017-05-10 [InstanceEdit:9709130] Jassal, Bijay, 2020-12-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9928932] D'Eustachio, Peter, 2024-11-18 [InstanceEdit:9928940] D'Eustachio, Peter, 2024-11-18 [InstanceEdit:9929028] D'Eustachio, Peter, 2024-11-19
name	Cytosolic folate export across the plasma membrane SLC46A1 transports FOLA from cytosol to extracellular region
output	[SimpleEntity:200716] FOLA [extracellular region] [SimpleEntity:351626] H+ [extracellular region]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2007-08-21
reverseReaction	[Reaction:200729] SLC46A1 transports FOLA from extracellular region to cytosol [Homo sapiens] [Reaction:200646] Cytosolic folate export across the plasma membrane [Homo sapiens]
reviewed	[InstanceEdit:9929029] Hill, David P, 2024-11-19
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360215] R-HSA-200646.6
structureModified	[InstanceEdit:9928932] D'Eustachio, Peter, 2024-11-18
summation	[Summation:200655] SLC46A1 protein in the plasma membrane mediates the reversib...
(hasEvent)	[Pathway:196757] Metabolism of folate and pterines [Homo sapiens]
(reverseReaction)	[Reaction:200729] SLC46A1 transports FOLA from extracellular region to cytosol [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9939787] Update Tracker - [Reaction:200646] Cytosolic folate export across the plasma membrane - v92:[modifyText, removeInput, removeLiteratureReference, removeOutput]
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