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Details on Person UniProt:Q3KRB8 ARHGAP11B
| Class:Id | ReferenceGeneProduct:200622 |
|---|---|
| _chainChangeLog | chain:1-267 added on Fri February 6 2015;chain:1-267 for 200622 removed on Thu May 6 2021;transit peptide:1- for 200622 added on Thu May 6 2021;chain:-267 for 200622 added on Thu May 6 2021 |
| _displayName | UniProt:Q3KRB8 ARHGAP11B |
| _timestamp | 2025-08-15 21:18:21 |
| chain | transit peptide:1- chain:-267 |
| checksum | 6817B9B13951F4BA |
| comment | FUNCTION Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex (PubMed:25721503, PubMed:27957544, PubMed:30484771, PubMed:32554627, PubMed:33938018). Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis, thereby playing a key role in neocortex expansion (PubMed:25721503). Promotes the proliferation of basal progenitors by inhibiting the mitochondrial permeability transition pore (mPTP): delays the opening of the mPTP via interaction with ADP:ATP translocase, thereby increasing mitochondrial Ca(2+) concentration and inducing glutamine catabolism, which is required for basal progenitor proliferation (PubMed:31883789). Does not possess GTPase activator activity: the absence of GTPase activator activity is required to promote amplification of basal progenitors during neocortex development (PubMed:25721503, PubMed:27957544).SUBUNIT Interacts with ADP:ATP translocase components SLC25A4/ANT1 and SLC25A5/ANT2.SUBCELLULAR LOCATION Specifically expressed in radial glia cells of cortical neural stem and progenitor cells (NPCs) during neocortex development. Preferentially expressed in apical and basal radial glia (PubMed:25721503). Not detected in cortical neurons and cortical plate (PubMed:25721503).MISCELLANEOUS When expressed in embryonic mouse neocortex, promotes basal progenitor generation and self-renewal, and can increase cortical plate area and induce gyrification (PubMed:25721503, PubMed:33938018). Mice exhibit increased neocortical size and upper-layer neuron numbers persisting into adulthood (PubMed:33938018). Moreover, mice display altered neurobehaviour, characterized by an increased memory flexibility and a reduced anxiety level (PubMed:33938018). When expressed in the developing neocortex of the gyrencephalic ferret, strongly increases proliferative basal radial glia, a progenitor cell type thought to be instrumental for neocortical expansion, resulting in extension of the neurogenic period and an increase in upper-layer neurons (PubMed:30484771). As consequence, the postnatal ferret neocortex displays increased neuron density in the upper cortical layers and expands in both the radial and tangential dimensions (PubMed:30484771). Expression in fetal neocortex of the common marmoset increases the numbers of upper-layer neurons, promoting enlargement of the neocortex and inducing its folding (PubMed:32554627).MISCELLANEOUS ARHGAP11B arose from partial duplication of ARHGAP11A on the human lineage after separation from the chimpanzee lineage, but before the divergence from Neandertals.CAUTION Although it contains a Rho-GAP domains, does not have GTPase activator activity (PubMed:25721503, PubMed:27957544). The absence of GTPase activator activity is required to promote amplification of basal progenitors (PubMed:27957544). Restoring this activity abolishes ability to promote amplification of basal progenitors during neocortex development (PubMed:27957544). |
| created | [InstanceEdit:200623] Gopinathrao, G, 2007-07-23 15:59:25 |
| description | recommendedName: fullName evidence="11"Inactive Rho GTPase-activating protein 11B alternativeName: fullName evidence="11"Rho-type GTPase-activating protein 11B |
| geneName | ARHGAP11B FAM7B1 |
| identifier | Q3KRB8 |
| isSequenceChanged | FALSE |
| keyword | GTPase activation Mitochondrion Reference proteome Transit peptide |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | ARHGAP11B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9627827] ENSEMBL:ENSG00000285077 ARHGAP11B [Homo sapiens] |
| secondaryIdentifier | RHGBB_HUMAN |
| sequenceLength | 267 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:200617] ARHGAP11B [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q3KRB8 ARHGAP11B (200622)
