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Details on Person Formation of Malonyl-CoA from Acetyl-CoA (liver)

Class:Id	Reaction:200555
_displayName	Formation of Malonyl-CoA from Acetyl-CoA (liver)
_doRelease	TRUE
_timestamp	2024-04-12 19:41:43
authored	[InstanceEdit:76206] Gopinathrao, G, 2003-10-03 00:00:00
catalystActivity	[CatalystActivity:200565] acetyl-CoA carboxylase activity of Btn-ACACA [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:200562] Gopinathrao, G, 2007-07-20 19:34:32
input	[SimpleEntity:76183] Ac-CoA [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:111627] HCO3- [cytosol]
internalReviewed	[InstanceEdit:9907566] D'Eustachio, Peter, 2024-04-12
literatureReference	[LiteratureReference:201031] Human acetyl-CoA carboxylase: characterization, molecular cloning, and evidence for two isoforms [LiteratureReference:200999] Expression, purification, and characterization of human and rat acetyl coenzyme A carboxylase (ACC) isozymes [LiteratureReference:539096] Differential activation of recombinant human acetyl-CoA carboxylases 1 and 2 by citrate
modified	[InstanceEdit:201001] Gopinathrao, G, 2007-07-29 16:52:53 [InstanceEdit:539091] D'Eustachio, P, 2010-03-09 [InstanceEdit:539120] D'Eustachio, P, 2010-03-09 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9865851] D'Eustachio, Peter, 2024-03-19 [InstanceEdit:9907565] D'Eustachio, Peter, 2024-04-12 [InstanceEdit:9907580] D'Eustachio, Peter, 2024-04-12
name	Formation of Malonyl-CoA from Acetyl-CoA (liver) acetyl-CoA + ATP + hydrogencarbonate => ADP + H(+) + malonyl-CoA + phosphate
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29508] Mal-CoA [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:75848] ACLY tetramer transforms CIT to Ac-CoA [Homo sapiens] [Reaction:75849] SLC25A1 exchanges CIT and MAL [Homo sapiens] [BlackBoxEvent:163770] Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX [Homo sapiens] [BlackBoxEvent:163743] Transcriptional activation of ACACA by ChREBP:MLX [Homo sapiens] [Reaction:9856550] MLXIPL:MLX binds ACACA gene promoter [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
regulatedBy	[PositiveRegulation:539127] Positive regulation by 'CIT [cytosol]'
regulationReference	[RegulationReference:9641512] Positive regulation by 'CIT [cytosol]' Differential activation of recombinant human acetyl-CoA carboxylases 1 and 2 by citrate
releaseDate	2006-11-16
reviewed	[InstanceEdit:9907581] Hill, David P, 2024-04-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360122] R-HSA-200555.6
structureModified	[InstanceEdit:9865851] D'Eustachio, Peter, 2024-03-19
summation	[Summation:76211] Cytosolic acetyl-CoA carboxylase 1 (ACACA) catalyzes the rea...
(hasEvent)	[Pathway:75105] Fatty acyl-CoA biosynthesis [Homo sapiens]
(precedingEvent)	[Reaction:75872] Conversion of malonyl-CoA and acetyl-CoA to palmitate [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9782886] Update Tracker - [Reaction:200555] acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate - v58:[modifyText] [_UpdateTracker:9790677] Update Tracker - [Reaction:200555] acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate - v33:[addLiteratureReference, addRegulator, modifyText] [_UpdateTracker:9846632] Update Tracker - [Reaction:200555] acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate - v84:[modifyText] [_UpdateTracker:9911076] Update Tracker - [Reaction:200555] Formation of Malonyl-CoA from Acetyl-CoA (liver) - v89:[addOutput]
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