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Details on Person NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD

Class:Id	Reaction:200512
_displayName	NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD
_doRelease	TRUE
_timestamp	2025-06-02 17:49:50
authored	[InstanceEdit:200480] D'Eustachio, P, 2007-07-19 16:12:23
catalystActivity	[CatalystActivity:200481] nicotinate-nucleotide adenylyltransferase activity of 6xNMNAT1:6xZn2+ [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:200480] D'Eustachio, P, 2007-07-19 16:12:23
crossReference	[DatabaseIdentifier:9938183] RHEA:21361
edited	[InstanceEdit:8940089] Jassal, Bijay, 2016-09-23
input	[SimpleEntity:200492] NAMN [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:9668967] H+ [nucleoplasm]
internalReviewed	[InstanceEdit:9938268] D'Eustachio, Peter, 2025-02-11
literatureReference	[LiteratureReference:200498] Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms [LiteratureReference:200485] Initial-rate kinetics of human NMN-adenylyltransferases: substrate and metal ion specificity, inhibition by products and multisubstrate analogues, and isozyme contributions to NAD+ biosynthesis [LiteratureReference:200497] Characterization of recombinant human nicotinamide mononucleotide adenylyl transferase (NMNAT), a nuclear enzyme essential for NAD synthesis [LiteratureReference:200471] Structure of human nicotinamide/nicotinic acid mononucleotide adenylyltransferase. Basis for the dual substrate specificity and activation of the oncolytic agent tiazofurin.
modified	[InstanceEdit:732460] D'Eustachio, P, 2010-05-12 [InstanceEdit:8878980] D'Eustachio, Peter, 2016-07-14 [InstanceEdit:8939958] Jassal, Bijay, 2016-09-22 [InstanceEdit:8940088] Jassal, Bijay, 2016-09-23 [InstanceEdit:8940091] Jassal, Bijay, 2016-09-23 [InstanceEdit:8942352] Jassal, Bijay, 2016-10-13 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9655301] D'Eustachio, Peter, 2019-07-24 [InstanceEdit:9748648] D'Eustachio, Peter, 2021-07-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9938178] D'Eustachio, Peter, 2025-02-10 [InstanceEdit:9938269] D'Eustachio, Peter, 2025-02-11 [InstanceEdit:9953438] D'Eustachio, Peter, 2025-06-02
name	NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD beta-nicotinamide D-ribonucleotide + ATP + H(+) => diphosphate + NAD(+) Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1]
output	[SimpleEntity:200499] NAAD [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm]
precedingEvent	[Reaction:197268] QPRT transfers PRIB to QUIN to form NAMN [Homo sapiens] [Reaction:197187] ACS transforms to QUIN non-enzymatically [Homo sapiens] [Reaction:197250] NAMPT transfers PRIB to NAM to form NAMN [Homo sapiens] [BlackBoxEvent:1368889] Expression of NAMPT (NamPRT, PBEF, Visfatin) [Homo sapiens] [Reaction:8869606] NMRK1 phosphorylates NAR to yield NAMN [Homo sapiens] [Reaction:8869607] NMRK2 phosphorylates NAR to yield NAMN [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2007-09-04
reviewed	[InstanceEdit:9953436] Hill, David P, 2025-06-02
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:8940089] Jassal, Bijay, 2016-09-23
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360962] R-HSA-200512.8
structureModified	[InstanceEdit:9938178] D'Eustachio, Peter, 2025-02-10
summation	[Summation:200482] NMNAT1 catalyzes the reaction of nicotinate D-ribonucleotide...
(hasEvent)	[Pathway:196807] Nicotinate metabolism [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775549] Update Tracker - [Reaction:200512] NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD - v78:[add_removeOutput] [_UpdateTracker:9777567] Update Tracker - [Reaction:200512] NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD - v70:[add_removeInput] [_UpdateTracker:9782879] Update Tracker - [Reaction:200512] NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD - v58:[add_removeInput, add_removeOutput] [_UpdateTracker:9939788] Update Tracker - [Reaction:200512] NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD - v92:[removeInput]
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