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Details on Person Exchange of acylcarnitine and carnitine across the inner mitochondrial membrane

Class:Id	Reaction:200424
_displayName	Exchange of acylcarnitine and carnitine across the inner mitochondrial membrane
_doRelease	TRUE
_timestamp	2025-11-15 08:55:57
authored	[InstanceEdit:201063] Gopinathrao, G, 2007-07-29 21:03:03
catalystActivity	[CatalystActivity:200567] carnitine:O-acyl-L-carnitine antiporter activity of SLC25A20 [mitochondrial inner membrane]
catalystActivityReference	[CatalystActivityReference:9643149] carnitine:acyl carnitine antiporter activity of SLC25A20 [mitochondrial inner membrane] Cloning of the human carnitine-acylcarnitine carrier cDNA and identification of the molecular defect in a patient
compartment	[Compartment:17927] mitochondrial intermembrane space [Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:200415] Gopinathrao, G, 2007-07-18 19:50:24
crossReference	[DatabaseIdentifier:9971093] RHEA:49926
input	[SimpleEntity:201023] CAR [mitochondrial matrix] [DefinedSet:9971099] Acyl-CAR [mitochondrial intermembrane space]
internalReviewed	[InstanceEdit:9971584] D'Eustachio, Peter, 2025-11-07
literatureReference	[LiteratureReference:201067] Cloning of the human carnitine-acylcarnitine carrier cDNA and identification of the molecular defect in a patient
modified	[InstanceEdit:200562] Gopinathrao, G, 2007-07-20 19:34:32 [InstanceEdit:201001] Gopinathrao, G, 2007-07-29 16:52:53 [InstanceEdit:201062] Gopinathrao, G, 2007-07-29 16:59:33 [InstanceEdit:201070] Gopinathrao, G, 2007-07-30 14:54:02 [InstanceEdit:201092] Gopinathrao, G, 2007-07-31 11:22:43 [InstanceEdit:201317] Gopinathrao, G, 2007-08-03 18:51:55 [InstanceEdit:549212] D'Eustachio, P, 2010-03-18 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9911357] D'Eustachio, Peter, 2024-05-29 [InstanceEdit:9971108] Stephan, Ralf, 2025-11-04 [InstanceEdit:9971587] D'Eustachio, Peter, 2025-11-07 [InstanceEdit:9971589] D'Eustachio, Peter, 2025-11-07 [InstanceEdit:9973674] Stephan, Ralf, 2025-11-15
name	Exchange of acylcarnitine and carnitine across the inner mitochondrial membrane (R)-carnitine(in) + O-acyl-(R)-carnitine(out) = (R)-carnitine(out) + O-acyl-(R)-carnitine(in)
output	[SimpleEntity:549207] CAR [mitochondrial intermembrane space] [DefinedSet:9971097] Acyl-CAR [mitochondrial matrix]
precedingEvent	[Reaction:200406] CPT1A transfers PALM to CAR [Homo sapiens] [BlackBoxEvent:8949399] CAR translocates from the cytosol to the mitochondrial intermembrane space [Homo sapiens] [Reaction:434382] ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A [Homo sapiens] [Reaction:5634100] FABP5 dissociates from RXRA:PPARD:atRA [Homo sapiens] [Reaction:9911362] CPT1B transfers PALM to CAR [Homo sapiens] [BlackBoxEvent:8949399] CAR translocates from the cytosol to the mitochondrial intermembrane space [Homo sapiens] [Reaction:434382] ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A [Homo sapiens] [Reaction:5634100] FABP5 dissociates from RXRA:PPARD:atRA [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2007-09-04
reviewed	[InstanceEdit:201322] D'Eustachio, P, 2007-07-31 18:50:15 [InstanceEdit:9971588] D'Eustachio, Peter, 2025-11-07
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360988] R-HSA-200424.7
structureModified	[InstanceEdit:9971108] Stephan, Ralf, 2025-11-04
summation	[Summation:201025] The carnitine-acylcarnitine transporter (SLC25A20 / CACT), e...
(hasEvent)	[Pathway:200425] Carnitine shuttle [Homo sapiens]
(precedingEvent)	[Reaction:200410] CPT2 converts acylcarnitine to acyl-CoA [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790394] Update Tracker - [Reaction:200424] Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane - v33:[add_removeOutput, modifyText] [_UpdateTracker:9971793] Update Tracker - [Reaction:200424] Exchange of acylcarnitine and carnitine across the inner mitochondrial membrane - v95:[add_removeInput, add_removeOutput]
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