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Details on Person pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis

Class:Id	Reaction:200423
_displayName	pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis
_doRelease	TRUE
_timestamp	2024-08-02 17:57:13
authored	[InstanceEdit:201063] Gopinathrao, G, 2007-07-29 21:03:03
catalystActivity	[CatalystActivity:200412] AMP-activated protein kinase activity of AMPK heterotrimer (active) [cytosol]
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:200415] Gopinathrao, G, 2007-07-18 19:50:24
crossReference	[DatabaseIdentifier:9857128] RHEA:17990
edited	[InstanceEdit:8876886] Jassal, Bijay, 2016-06-17
goBiologicalProcess	[GO_BiologicalProcess:260763] fatty acid homeostasis
input	[Polymer:8867341] Btn-ACACB:2Mn2+ polymer [mitochondrial outer membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
internalReviewed	[InstanceEdit:9911507] D'Eustachio, Peter, 2024-05-31
literatureReference	[LiteratureReference:201369] AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome
modified	[InstanceEdit:200451] Gopinathrao, G, 2007-07-18 21:17:53 [InstanceEdit:200452] Gopinathrao, G, 2007-07-18 21:19:17 [InstanceEdit:200453] Gopinathrao, G, 2007-07-18 21:20:57 [InstanceEdit:200562] Gopinathrao, G, 2007-07-20 19:34:32 [InstanceEdit:201001] Gopinathrao, G, 2007-07-29 16:52:53 [InstanceEdit:201062] Gopinathrao, G, 2007-07-29 16:59:33 [InstanceEdit:201085] Gopinathrao, G, 2007-07-30 15:43:15 [InstanceEdit:201092] Gopinathrao, G, 2007-07-31 11:22:43 [InstanceEdit:201317] Gopinathrao, G, 2007-08-03 18:51:55 [InstanceEdit:201368] Gopinathrao, G, 2007-08-06 22:27:00 [InstanceEdit:388849] Jassal, B, 2008-12-16 11:42:10 [InstanceEdit:599717] D'Eustachio, P, 2010-04-15 [InstanceEdit:8876895] Jassal, Bijay, 2016-06-17 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9911357] D'Eustachio, Peter, 2024-05-29 [InstanceEdit:9911506] D'Eustachio, Peter, 2024-05-31 [InstanceEdit:9917363] D'Eustachio, Peter, 2024-08-02
name	pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis ATP + L-seryl-(protein) => ADP + H(+) + O-phospho-L-seryl-(protein)
output	[Polymer:8876893] Btn-p-S222-ACACB:2Mn2+ polymer [mitochondrial outer membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:200421] Activation of cytosolic AMPK by phosphorylation [Homo sapiens] [Reaction:380942] LKB1 forms a trimeric complex with STRAD and MO25 [Homo sapiens] [Reaction:380930] Phosphorylated AMPK binds AMP [Homo sapiens] [Reaction:200421] Activation of cytosolic AMPK by phosphorylation [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2005-09-26
reviewed	[InstanceEdit:201322] D'Eustachio, P, 2007-07-31 18:50:15 [InstanceEdit:9917333] Hill, David P, 2024-08-02
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:8876886] Jassal, Bijay, 2016-06-17
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360116] R-HSA-200423.4
structureModified	[InstanceEdit:9911357] D'Eustachio, Peter, 2024-05-29
summation	[Summation:201087] Acetyl-CoA carboxylase 2 (ACACB, ACC2) is involved in the re...
(hasEvent)	[Pathway:200425] Carnitine shuttle [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9782916] Update Tracker - [Reaction:200423] pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis - v58:[add_removeInput, add_removeOutput, modifyText] [_UpdateTracker:9785995] Update Tracker - [Reaction:200423] pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis - v50:[modifyText] [_UpdateTracker:9790486] Update Tracker - [Reaction:200423] pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis - v33:[addInput, addOutput] [_UpdateTracker:9919510] Update Tracker - [Reaction:200423] pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis - v90:[removeOutput]
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