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Details on Person Activation of cytosolic AMPK by phosphorylation

Class:IdReaction:200421
_displayNameActivation of cytosolic AMPK by phosphorylation
_doReleaseTRUE
_timestamp2015-05-14 14:43:39
authored[InstanceEdit:201063] Gopinathrao, G, 2007-07-29 21:03:03
catalystActivity[CatalystActivity:380980] protein serine/threonine kinase activity of LKB1:STRAD:MO25 [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:200415] Gopinathrao, G, 2007-07-18 19:50:24
edited[InstanceEdit:447056] Jassal, B, 2009-11-20
input[Complex:380961] AMPK heterotrimer [cytosol] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
literatureReference[LiteratureReference:200450] Effect of phosphorylation by AMP-activated protein kinase on palmitoyl-CoA inhibition of skeletal muscle acetyl-CoA carboxylase
[LiteratureReference:200449] Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise
[LiteratureReference:200444] Isoform-specific and exercise intensity-dependent activation of 5'-AMP-activated protein kinase in human skeletal muscle
[LiteratureReference:380943] The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
[LiteratureReference:447060] Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
[LiteratureReference:164135] LKB1 is the upstream kinase in the AMP-activated protein kinase cascade
modified[InstanceEdit:200434] Gopinathrao, G, 2007-07-18 20:56:23
[InstanceEdit:200451] Gopinathrao, G, 2007-07-18 21:17:53
[InstanceEdit:200562] Gopinathrao, G, 2007-07-20 19:34:32
[InstanceEdit:201062] Gopinathrao, G, 2007-07-29 16:59:33
[InstanceEdit:201092] Gopinathrao, G, 2007-07-31 11:22:43
[InstanceEdit:201317] Gopinathrao, G, 2007-08-03 18:51:55
[InstanceEdit:388851] Jassal, B, 2008-12-16 13:38:33
[InstanceEdit:447056] Jassal, B, 2009-11-20
[InstanceEdit:449022] Jassal, B, 2009-11-27
[InstanceEdit:500332] Jassal, B, 2010-02-03
[InstanceEdit:5687546] Jupe, Steve, 2015-04-08
[InstanceEdit:5687631] Jupe, Steve, 2015-04-08
[InstanceEdit:5693184] Jupe, Steve, 2015-05-14
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameActivation of cytosolic AMPK by phosphorylation
output[Complex:380934] p-AMPK heterotrimer [cytosol] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
regulatedBy[PositiveRegulation:201329] Positive regulation by 'adenosine 5'-monophosphate [cytosol]'
releaseDate2010-03-16
reviewed[InstanceEdit:5693188] Zwartkruis, Fried J T, 2015-05-14
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:5687545] Jupe, Steve, 2015-04-08
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361421] R-HSA-200421.3
summation[Summation:200442] The AMP-activated protein kinase (AMPK) is a highly conserve...
(hasEvent)[Pathway:380972] Energy dependent regulation of mTOR by LKB1-AMPK [Homo sapiens]
(precedingEvent)[Reaction:200423] pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis [Homo sapiens]
[Reaction:380930] Phosphorylated AMPK binds AMP [Homo sapiens]
[Reaction:380949] AMPK is dephosphorylated [Homo sapiens]
(updatedInstance)[_UpdateTracker:9783782] Update Tracker - [Reaction:200421] Activation of cytosolic AMPK by phosphorylation - v55:[removeRegulator]
[_UpdateTracker:9784710] Update Tracker - [Reaction:200421] Activation of cytosolic AMPK by phosphorylation - v53:[modifyText]
[_UpdateTracker:9785135] Update Tracker - [Reaction:200421] Activation of cytosolic AMPK by phosphorylation - v52:[modifyText]
[_UpdateTracker:9791295] Update Tracker - [Reaction:200421] Activation of cytosolic AMPK by phosphorylation - v31:[addLiteratureReference, modifyText]
[_UpdateTracker:9791566] Update Tracker - [Reaction:200421] Activation of cytosolic AMPK by phosphorylation - v28:[addLiteratureReference, add_removeCatalystActivity, add_removeInput, add_removeOutput, modifyText]
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