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Details on Person CPT1A transfers PALM to CAR

Class:IdReaction:200406
_displayNameCPT1A transfers PALM to CAR
_doReleaseTRUE
_timestamp2024-06-03 14:19:52
authored[InstanceEdit:201063] Gopinathrao, G, 2007-07-29 21:03:03
catalystActivity[CatalystActivity:201041] carnitine O-palmitoyltransferase activity of CPT1A [mitochondrial outer membrane]
catalystActivityReference[CatalystActivityReference:9911360] carnitine O-palmitoyltransferase activity of CPT1A [mitochondrial outer membrane] Functional and structural basis of carnitine palmitoyltransferase 1A deficiency
compartment[Compartment:70101] cytosol
[Compartment:17906] mitochondrial outer membrane
[Compartment:17927] mitochondrial intermembrane space
created[InstanceEdit:200415] Gopinathrao, G, 2007-07-18 19:50:24
crossReference[DatabaseIdentifier:9911369] RHEA:12662
edited[InstanceEdit:200415] Gopinathrao, G, 2007-07-18 19:50:24
input[SimpleEntity:549207] CAR [mitochondrial intermembrane space]
[SimpleEntity:200993] PALM-CoA [cytosol]
literatureReference[LiteratureReference:201014] Functional and structural basis of carnitine palmitoyltransferase 1A deficiency
[LiteratureReference:549206] Molecular basis of hepatic carnitine palmitoyltransferase I deficiency
[LiteratureReference:201018] Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain
[LiteratureReference:549204] Structural model of carnitine palmitoyltransferase I based on the carnitine acetyltransferase crystal
[LiteratureReference:201072] Structure-function relationships of the liver and muscle isoforms of carnitine palmitoyltransferase I
[LiteratureReference:549202] Functional studies of yeast-expressed human heart muscle carnitine palmitoyltransferase I
[LiteratureReference:5423014] Induction of carnitine palmitoyl transferase 1 and fatty acid oxidation by retinoic acid in HepG2 cells
modified[InstanceEdit:200562] Gopinathrao, G, 2007-07-20 19:34:32
[InstanceEdit:201001] Gopinathrao, G, 2007-07-29 16:52:53
[InstanceEdit:201061] Gopinathrao, G, 2007-07-29 16:58:10
[InstanceEdit:201062] Gopinathrao, G, 2007-07-29 16:59:33
[InstanceEdit:201070] Gopinathrao, G, 2007-07-30 14:54:02
[InstanceEdit:201092] Gopinathrao, G, 2007-07-31 11:22:43
[InstanceEdit:201317] Gopinathrao, G, 2007-08-03 18:51:55
[InstanceEdit:549212] D'Eustachio, P, 2010-03-18
[InstanceEdit:5423008] Jassal, Bijay, 2014-05-08
[InstanceEdit:5423021] Jassal, Bijay, 2014-05-08
[InstanceEdit:5615674] Jassal, Bijay, 2014-07-28
[InstanceEdit:8878492] Jassal, Bijay, 2016-07-07
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:8949394] D'Eustachio, Peter, 2016-11-23
[InstanceEdit:8949400] D'Eustachio, Peter, 2016-11-23
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9632681] May, Bruce, 2018-12-20
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9911357] D'Eustachio, Peter, 2024-05-29
[InstanceEdit:9911645] D'Eustachio, Peter, 2024-06-03
nameCPT1A transfers PALM to CAR
palmitoyl-CoA + carnitine => palmitoylcarnitine + CoASH
(R)-carnitine + hexadecanoyl-CoA => CoA + O-hexadecanoyl-(R)-carnitine
output[SimpleEntity:76194] CoA-SH [cytosol]
[SimpleEntity:201034] L-PCAR [mitochondrial intermembrane space]
precedingEvent
regulatedBy[NegativeRegulation:200418] Negative regulation by 'Mal-CoA [cytosol]'
[PositiveRegulation:5422944] Positive regulation by 'RXRA:PPARD:atRA [nucleoplasm]'
regulationReference[RegulationReference:9642880] Negative regulation by 'Mal-CoA [cytosol]' Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain
releaseDate2005-09-26
reviewed[InstanceEdit:201322] D'Eustachio, P, 2007-07-31 18:50:15
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:5423020] Jassal, Bijay, 2014-05-08
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359668] R-HSA-200406.9
summation[Summation:201082] Carnitine palmitoyl transferase 1A (CPT1A) associated with t...
(hasEvent)[Pathway:200425] Carnitine shuttle [Homo sapiens]
(precedingEvent)[Reaction:200424] Exchange of acylcarnitine and carnitine across the inner mitochondrial membrane [Homo sapiens]
(updatedInstance)[_UpdateTracker:9777640] Update Tracker - [Reaction:200406] CPT1A,B transfers PALM to CAR - v70:[modifyText]
[_UpdateTracker:9782707] Update Tracker - [Reaction:200406] CPT1A,B transfers PALM to CAR - v58:[modifyText]
[_UpdateTracker:9785556] Update Tracker - [Reaction:200406] CPT1A,B transfers PALM to CAR - v51:[add_removeRegulator]
[_UpdateTracker:9786598] Update Tracker - [Reaction:200406] CPT1A,B transfers PALM to CAR - v49:[addLiteratureReference, addRegulator, modifyText]
[_UpdateTracker:9790681] Update Tracker - [Reaction:200406] CPT1A,B transfers PALM to CAR - v33:[addInput, addOutput, add_removeLiteratureReference, modifyText]
[_UpdateTracker:9919369] Update Tracker - [Reaction:200406] CPT1A transfers PALM to CAR - v90:[modifyText]
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