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| Class:Id | Summation:199896 |
|---|---|
| _displayName | Nerve growth factor (NGF) activates multiple signalling path... |
| _timestamp | 2007-11-16 13:45:50 |
| created | [InstanceEdit:199916] Jassal, B, 2007-07-13 13:44:04 |
| modified | [InstanceEdit:203799] Jassal, B, 2007-11-16 13:45:02 |
| text | Nerve growth factor (NGF) activates multiple signalling pathways that mediate the phosphorylation of CREB at the critical regulatory site, serine 133. CREB phosphorylation at serine 133 is a crucial event in neurotrophin signalling, being mediated by ERK/RSK, ERK/MSK1 and p38/MAPKAPK2 pathways. Several kinases, such as MSK1, RSK1/2/3 (MAPKAPK1A/B/C), and MAPKAPK2, are able to directly phosphorylate CREB at S133. MSK1 is also able to activate ATF (Cyclic-AMP-dependent transcription factor). However, the NGF-induced CREB phosphorylation appears to correlate better with activation of MSK1 rather than RSK1/2/3, or MAPKAPK2. In retrograde signalling, activation of CREB occurs within 20 minutes after neurotrophin stimulation of distal axons. |
| (summation) | [Pathway:199920] CREB phosphorylation [Homo sapiens] |
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