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Details on Person AKT can phosphorylate NR4A1 (NUR77)

Class:IdReaction:199863
_displayNameAKT can phosphorylate NR4A1 (NUR77)
_doReleaseTRUE
_timestamp2017-07-28 15:02:33
authored[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
catalystActivity[CatalystActivity:199274] protein serine/threonine kinase activity of p-T,p-S-AKT [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:199866] Jassal, B, 2007-07-12 14:41:47
goBiologicalProcess[GO_BiologicalProcess:172430] phosphatidylinositol 3-kinase/protein kinase B signal transduction
input[EntityWithAccessionedSequence:199831] NR4A1 [nucleoplasm] [Homo sapiens]
[SimpleEntity:29358] ATP [nucleoplasm]
literatureReference[LiteratureReference:199827] Akt phosphorylates and regulates the orphan nuclear receptor Nur77
modified[InstanceEdit:202667] Jassal, B, 2007-11-08 15:44:30
[InstanceEdit:211298] Jassal, B, 2008-01-30 10:40:56
[InstanceEdit:215417] Jassal, B, 2008-02-28 15:14:23
[InstanceEdit:1262966] Jassal, B, 2011-05-06
[InstanceEdit:1273428] Jassal, B, 2011-05-11
[InstanceEdit:2400004] Orlic-Milacic, M, 2012-07-13
[InstanceEdit:9014477] Orlic-Milacic, Marija, 2017-07-28
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameAKT can phosphorylate NR4A1 (NUR77)
output[EntityWithAccessionedSequence:199846] p-S351-NR4A1 [nucleoplasm] [Homo sapiens]
[SimpleEntity:113582] ADP [nucleoplasm]
precedingEvent
releaseDate2008-03-12
reviewed[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361575] R-HSA-199863.3
summation[Summation:199824] AKT inhibits DNA binding of NUR77 and inhibits its pro-apopt...
(hasEvent)[Pathway:198693] AKT phosphorylates targets in the nucleus [Homo sapiens]
(normalReaction)[Reaction:2399988] AKT1 E17K mutant phosphorylates NR4A1 (NUR77) [Homo sapiens]
(updatedInstance)[_UpdateTracker:9789245] Update Tracker - [Reaction:199863] AKT can phosphorylate NR4A1 (NUR77) - v38:[modifyText]
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No pathways have been reviewed or authored by AKT can phosphorylate NR4A1 (NUR77) (199863)