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Details on Person p-6Y-EGFR D770_N771insNPG [plasma membrane]

Class:Id	EntityWithAccessionedSequence:1996335
_displayName	p-6Y-EGFR D770_N771insNPG [plasma membrane]
_timestamp	2023-03-20 18:24:59
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:1996337] Orlic-Milacic, Marija, 2011-11-19
disease	[Disease:1500689] cancer [Disease:1500699] lung cancer [Disease:1247848] non-small cell lung carcinoma
endCoordinate	1210
hasModifiedResidue	[ModifiedResidue:182927] O4'-phospho-L-tyrosine at 1069 [ModifiedResidue:179797] O4'-phospho-L-tyrosine at 1092 [ModifiedResidue:179834] O4'-phospho-L-tyrosine at 1110 [ModifiedResidue:179844] O4'-phospho-L-tyrosine at 1172 [ModifiedResidue:179872] O4'-phospho-L-tyrosine at 1197 [ModifiedResidue:180321] O4'-phospho-L-tyrosine at 1016 [FragmentReplacedModification:9831473] Replacement of residues 770 to 771 by DNPGN
literatureReference	[LiteratureReference:9831470] Structural, biochemical, and clinical characterization of epidermal growth factor receptor (EGFR) exon 20 insertion mutations in lung cancer
modified	[InstanceEdit:3662293] Orlic-Milacic, M, 2013-06-06 [InstanceEdit:9831478] Orlic-Milacic, Marija, 2023-03-20
name	p-6Y-EGFR D770_N771insNPG Phosphorylated Epidermal Growth Factor Receptor D770_N771insNPG p-6Y-EGFR Asp770_Asn771insAsnProGly
referenceEntity	[ReferenceGeneProduct:54208] UniProt:P00533 EGFR [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2018258] R-HSA-1996335.2
startCoordinate	25
(hasCandidate)	[CandidateSet:1182982] Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9888020] Update Tracker - [EntityWithAccessionedSequence:1996335] p-6Y-EGFR D770_N771insNPG [plasma membrane] - v46:[modifyName] [_UpdateTracker:9905399] Update Tracker - [EntityWithAccessionedSequence:1996335] p-6Y-EGFR D770_N771insNPG [plasma membrane] - v85:[addLiteratureReference, add_removeHasModifiedResidue]
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No pathways have been reviewed or authored by p-6Y-EGFR D770_N771insNPG [plasma membrane] (1996335)