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Details on Person SLC19A2/3 transport extracellular THMN to cytosol

Class:Id	Reaction:199626
_displayName	SLC19A2/3 transport extracellular THMN to cytosol
_doRelease	TRUE
_timestamp	2013-02-22 16:18:21
authored	[InstanceEdit:199631] D'Eustachio, P, 2007-07-11 18:15:46
catalystActivity	[CatalystActivity:199654] thiamine transmembrane transporter activity of SLC19A2/3 [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:199631] D'Eustachio, P, 2007-07-11 18:15:46
input	[SimpleEntity:199622] THMN [extracellular region]
literatureReference	[LiteratureReference:199640] Thiamin uptake by the human-derived renal epithelial (HEK-293) cells: cellular and molecular mechanisms [LiteratureReference:199655] Mutations in a new gene encoding a thiamine transporter cause thiamine-responsive megaloblastic anaemia syndrome [LiteratureReference:199642] The gene mutated in thiamine-responsive anaemia with diabetes and deafness (TRMA) encodes a functional thiamine transporter [LiteratureReference:199651] Mutations in SLC19A2 cause thiamine-responsive megaloblastic anaemia associated with diabetes mellitus and deafness [LiteratureReference:199657] Expression and functional contribution of hTHTR-2 in thiamin absorption in human intestine [LiteratureReference:199666] Targeting and trafficking of the human thiamine transporter-2 in epithelial cells [LiteratureReference:199658] Biotin-responsive basal ganglia disease-linked mutations inhibit thiamine transport via hTHTR2: biotin is not a substrate for hTHTR2
modified	[InstanceEdit:199669] D'Eustachio, P, 2007-07-11 18:17:05 [InstanceEdit:200987] Gopinathrao, G, 2007-07-27 15:28:23 [InstanceEdit:201332] Gopinathrao, G, 2007-08-06 14:46:29 [InstanceEdit:732460] D'Eustachio, P, 2010-05-12 [InstanceEdit:3165246] Jassal, B, 2013-02-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SLC19A2/3 transport extracellular THMN to cytosol Thiamin transport across the plasma membrane thiamin [extracellular] => thiamin [cytosol]
output	[SimpleEntity:196934] THMN [cytosol]
releaseDate	2007-08-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358360] R-HSA-199626.2
summation	[Summation:199646] Two transport proteins, SLC19A2 (THTR1) and SLC19A3 (THTR2),...
(hasEvent)	[Pathway:196819] Vitamin B1 (thiamin) metabolism [Homo sapiens]
(precedingEvent)	[Reaction:196761] 2xTPK1:Mg2+ phosphorylates THMN [Homo sapiens]
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No pathways have been reviewed or authored by SLC19A2/3 transport extracellular THMN to cytosol (199626)