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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person Leukocyte immunoglobulin (Ig)-like receptors [LILRs, also kn...

Class:IdSummation:199607
_displayNameLeukocyte immunoglobulin (Ig)-like receptors [LILRs, also kn...
_timestamp2007-07-11 15:38:37
created[InstanceEdit:199606] de Bono, B, 2007-07-11 15:27:12
literatureReference[LiteratureReference:199042] The LILR family: modulators of innate and adaptive immune pathways in health and disease
modified[InstanceEdit:199610] de Bono, B, 2007-07-11 15:37:06
textLeukocyte immunoglobulin (Ig)-like receptors [LILRs, also known as Ig-like transcripts (ILTs)] are a family of inhibitory and stimulatory receptors encoded within the leukocyte receptor complex and are expressed by immune cell types of both myeloid and lymphoid lineage. Several members of the LILR family recognize major histocompatibility complex class I. The immunomodulatory role of LILR receptors indicates that they may exert an influence on signaling pathways of both innate and adaptive immune systems.

Signaling mechanisms are employed that are similar to the ones adopted by the closely related killer cell inhibitory receptors (KIRs). ITIMs recruit inhibitory phosphatases that dephosphorylate ITIM and ITAM domains in order to influence intracellular signaling cascades. In contrast, activating LILRs, which lack any signaling domains of their own, rely on association with an adaptor protein such as FceRI-gamma to transmit their signal through its intracellular ITAMs.

(summation)[Reaction:199043] LILRs interact with MHC Class I [Homo sapiens]
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