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Details on Person UniProt:C1JZ66 KPNA7
| Class:Id | ReferenceGeneProduct:1995873 |
|---|---|
| _chainChangeLog | chain:1-522 added on Sat February 7 2015 |
| _displayName | UniProt:C1JZ66 KPNA7 |
| _timestamp | 2024-02-26 04:31:20 |
| chain | chain:1-522 |
| checksum | 09EDF7D4F2E6D1F4 |
| comment | FUNCTION Functions in nuclear protein import.SUBUNIT Binds to importin subunit beta-1/KPNB1 via the IBB domain; this complex dissociates in the presence of RAN-GTP. Shows a limited binding to the RB1 nuclear localization signal (NLS), but not to the SV40, nor NPM1 NLSs. Interacts with RSL1D1 (By similarity). Binds to the NPM2 nuclear localization signal.SUBCELLULAR LOCATION Expressed almost exclusively in ovary, in germinal vesicle (GV)-stage oocytes, but not in granulosa, nor theca cells. Detected at very low levels in testis.DEVELOPMENTAL STAGE Expressed at high levels in GV- and MII-stage oocytes, as well as in 2-cell embryos. Levels drop sharply by the blastocyst stage (at protein level). Not detectable in fetal ovaries 90 and 95 days of gestation, but highly abundant in fetal ovaries of late gestation.SIMILARITY Belongs to the importin alpha family. |
| created | [InstanceEdit:1995863] Weiser, JD |
| description | recommendedName: Importin subunit alpha-8 alternativeName: Karyopherin subunit alpha-7 |
| geneName | KPNA7 |
| identifier | C1JZ66 |
| isSequenceChanged | FALSE |
| keyword | Nucleus Protein transport Reference proteome Repeat Transport |
| modified | [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 |
| name | KPNA7 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | IMA8_BOVIN F1MPD2 |
| sequenceLength | 522 |
| species | [Species:48898] Bos taurus |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:C1JZ66 KPNA7 (1995873)
