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Details on Person UniProt:B3LTI7 SEC11
| Class:Id | ReferenceGeneProduct:1995872 |
|---|---|
| _chainChangeLog | chain:1-167 added on Sat February 7 2015 |
| _displayName | UniProt:B3LTI7 SEC11 |
| _timestamp | 2026-02-20 22:15:53 |
| chain | chain:1-167 |
| checksum | FC877232D6888DF3 |
| comment | FUNCTION Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (By similarity).CATALYTIC ACTIVITY Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.SUBUNIT Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3 (By similarity). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity). SPC associates with the translocon complex (By similarity).SUBCELLULAR LOCATION The C-terminal short (CTS) helix is essential for catalytic activity. It may be accommodated as a transmembrane helix in the thinned membrane environment of the complex, similarly to the signal peptide in the complex substrates.SIMILARITY Belongs to the peptidase S26B family. |
| created | [InstanceEdit:1995863] Weiser, JD |
| description | recommendedName: Signal peptidase complex catalytic subunit SEC11 ecNumber evidence="1"3.4.21.89 alternativeName: Secretory protein 11 alternativeName: Signal peptidase I |
| geneName | SEC11 SCRG_05156 |
| identifier | B3LTI7 |
| isSequenceChanged | FALSE |
| keyword | Endoplasmic reticulum Glycoprotein Hydrolase Membrane Protease Reference proteome Signal-anchor Transmembrane Transmembrane helix |
| modified | [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9773244] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | SEC11 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | SEC11_YEAS1 |
| sequenceLength | 167 |
| species | [Species:68322] Saccharomyces cerevisiae |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:B3LTI7 SEC11 (1995872)
