Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q8BRK9-2 Man2a2
| Class:Id | ReferenceIsoform:1995870 |
|---|---|
| _chainChangeLog | chain:1-1152 added on Fri February 6 2015 |
| _displayName | UniProt:Q8BRK9-2 Man2a2 |
| _timestamp | 2025-08-15 21:39:09 |
| chain | chain:1-1152 |
| checksum | 8A6274E9671F92DF |
| comment | FUNCTION Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway (By similarity).CATALYTIC ACTIVITY N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 2 H2O = 2 alpha-D-mannopyranose + an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]COFACTOR Binds 1 zinc ion per subunit.PATHWAY Protein modification; protein glycosylation.SUBUNIT Homodimer; disulfide-linked (By similarity). Interacts with MGAT4D.SUBCELLULAR LOCATION Belongs to the glycosyl hydrolase 38 family. |
| created | [InstanceEdit:1995863] Weiser, JD |
| description | recommendedName: Alpha-mannosidase 2x ecNumber evidence="2"3.2.1.114 alternativeName: Alpha-mannosidase IIx shortName: Man IIx alternativeName: Mannosidase alpha class 2A member 2 alternativeName: Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase |
| geneName | Man2a2 Mana2x |
| identifier | Q8BRK9 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Coiled coil Disulfide bond Glycoprotein Glycosidase Golgi apparatus Hydrolase Membrane Metal-binding Reference proteome Signal-anchor Transmembrane Transmembrane helix Zinc |
| modified | [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9616384] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | Man2a2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | MA2A2_MOUSE Q3UVK1 |
| sequenceLength | 1152 |
| species | [Species:48892] Mus musculus |
| variantIdentifier | Q8BRK9-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q8BRK9-2 Man2a2 (1995870)
