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Details on Person PTEN dephosphorylates PIP3

Class:Id	Reaction:199456
_displayName	PTEN dephosphorylates PIP3
_doRelease	TRUE
_timestamp	2017-07-28 14:53:13
authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
catalystActivity	[CatalystActivity:199445] phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity of PTEN [cytosol]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:199435] Jassal, B, 2007-07-10 12:01:00
goBiologicalProcess	[GO_BiologicalProcess:263612] negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
input	[SimpleEntity:179838] PI(3,4,5)P3 [plasma membrane] [SimpleEntity:29356] H2O [cytosol]
literatureReference	[LiteratureReference:1675887] Membrane-binding and activation mechanism of PTEN [LiteratureReference:199432] The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate [LiteratureReference:1676004] The lipid phosphatase activity of PTEN is critical for its tumor supressor function [LiteratureReference:2317505] Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association [LiteratureReference:8948103] Purification and characterization of the phosphatidylinositol-3,4,5-trisphosphate phosphatase in bovine thymus
modified	[InstanceEdit:202683] Jassal, Bijay, 2007-11-08 [InstanceEdit:211298] Jassal, B, 2008-01-30 10:40:56 [InstanceEdit:215417] Jassal, B, 2008-02-28 15:14:23 [InstanceEdit:1262966] Jassal, B, 2011-05-06 [InstanceEdit:1273428] Jassal, B, 2011-05-11 [InstanceEdit:1306822] Jassal, B, 2011-05-27 [InstanceEdit:2463861] Orlic-Milacic, M, 2012-08-30 [InstanceEdit:8863123] D'Eustachio, Peter, 2016-03-04 [InstanceEdit:8874452] Weiser, JD [InstanceEdit:8940513] Orlic-Milacic, Marija, 2016-09-26 [InstanceEdit:8942965] Orlic-Milacic, Marija, 2016-10-21 [InstanceEdit:8948108] Orlic-Milacic, Marija, 2016-11-10 [InstanceEdit:8948110] Orlic-Milacic, Marija, 2016-11-10 [InstanceEdit:9014474] Orlic-Milacic, Marija, 2017-07-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PTEN dephosphorylates PIP3 PI(3,4,5)P3 is dephosphorylated to PI (4,5)P2 by PTEN at the plasma membrane
output	[SimpleEntity:179856] PI(4,5)P2 [plasma membrane] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[BlackBoxEvent:198266] PI3K produces PIP3 and other phosphatidyl inositides [Homo sapiens] [Reaction:198315] Active IRS recruits PI3K to the plasma membrane and activates it [Homo sapiens] [Reaction:1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane [Homo sapiens] [Reaction:1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane [Homo sapiens] [Reaction:199456] PTEN dephosphorylates PIP3 [Homo sapiens] [Reaction:1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane [Homo sapiens] [Reaction:1675773] PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane [Homo sapiens] [Reaction:1675949] PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane [Homo sapiens] [Reaction:1676109] PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane [Homo sapiens] [Reaction:1676145] PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane [Homo sapiens] [Reaction:2316434] PI3K phosphorylates PIP2 to PIP3 [Homo sapiens] [Reaction:1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane [Homo sapiens] [Reaction:1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane [Homo sapiens] [Reaction:177927] PI3K binds to EGF:EGFR:GRB2:GAB1 [Homo sapiens] [Reaction:1250189] Binding of PI3K to ERBB2:p-ERBB3 heterodimer [Homo sapiens] [Reaction:1306965] Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR [Homo sapiens] [Reaction:1250346] Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers [Homo sapiens] [Reaction:5654591] Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA [Homo sapiens] [Reaction:5654596] Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA [Homo sapiens] [Reaction:5654614] Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA [Homo sapiens] [Reaction:5654622] Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA [Homo sapiens] [Reaction:5654640] Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA [Homo sapiens] [Reaction:5654643] Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA [Homo sapiens] [Reaction:5654662] Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA [Homo sapiens] [Reaction:5654669] Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA [Homo sapiens] [Reaction:186780] PI3-kinase binds to the active receptor [Homo sapiens] [Reaction:198315] Active IRS recruits PI3K to the plasma membrane and activates it [Homo sapiens] [Reaction:205262] Direct recruitment of PI3K to p-KIT [Homo sapiens] [Reaction:388830] PI3K binds ICOS [Homo sapiens] [Reaction:202203] Recruitment of PI3K to plasma membrane [Homo sapiens] [Reaction:1250353] Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers [Homo sapiens] [Reaction:114542] RAC1,RAC2,RHOG activate PI3K [Homo sapiens] [BlackBoxEvent:9028505] Activated NTRK2 recruits PI3K [Homo sapiens] [Reaction:9603407] Activated NTRK3 binds PI3K [Homo sapiens] [BlackBoxEvent:2321904] PTEN mRNA translation negatively regulated by microRNAs [Homo sapiens] [Reaction:2318752] miR-26A microRNAs bind PTEN mRNA [Homo sapiens] [BlackBoxEvent:8944497] PTEN mRNA translation is negatively regulated by microRNAs [Homo sapiens] [Reaction:2318752] miR-26A microRNAs bind PTEN mRNA [Homo sapiens] [Reaction:8944483] miR-17 microRNA binds PTEN mRNA [Homo sapiens] [Reaction:8944522] miR-19a microRNA binds PTEN mRNA [Homo sapiens] [Reaction:8948569] miR-19b microRNA binds PTEN mRNA [Homo sapiens] [Reaction:8945709] miR-20 microRNAs bind PTEN mRNA [Homo sapiens] [Reaction:8944706] miR-21 nonendonucleolytic RISC binds PTEN mRNA [Homo sapiens] [Reaction:8944538] miR-22 microRNA binds PTEN mRNA [Homo sapiens] [Reaction:8944569] miR-25 microRNA binds PTEN mRNA [Homo sapiens] [Reaction:8944599] miR-93 microRNA binds PTEN mRNA [Homo sapiens] [Reaction:8944632] miR-106 microRNAs bind PTEN mRNA [Homo sapiens] [Reaction:8944684] miR-205 microRNA binds PTEN mRNA [Homo sapiens] [Reaction:8944650] miR-214 microRNA binds PTEN mRNA [Homo sapiens]
releaseDate	2008-03-12
releaseStatus	UPDATED
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37 [InstanceEdit:2247963] Wakelam, Michael, 2012-05-14 [InstanceEdit:2463860] Thorpe, Lauren, 2012-08-13 [InstanceEdit:2463859] Yuzugullu, Haluk, 2012-08-13 [InstanceEdit:2463854] Zhao, Jean J, 2012-08-13 [InstanceEdit:8948085] Leslie, Nicholas, 2016-09-30 [InstanceEdit:8948084] Kriplani, Nisha, 2016-09-30
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:2422427] Orlic-Milacic, M, 2012-07-18
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360218] R-HSA-199456.5
summation	[Summation:199419] At the plasma membrane, phosphatidylinositol-3,4,5-trisphosp...
(hasEvent)	[Pathway:199418] Negative regulation of the PI3K/AKT network [Homo sapiens] [Pathway:202424] Downstream TCR signaling [Homo sapiens] [Pathway:1660499] Synthesis of PIPs at the plasma membrane [Homo sapiens]
(normalReaction)	[FailedReaction:2317387] PTEN cancer mutants do not dephosphorylate PIP3 [Homo sapiens]
(precedingEvent)	[Reaction:1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane [Homo sapiens] [Reaction:1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane [Homo sapiens] [Reaction:1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane [Homo sapiens] [Reaction:1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane [Homo sapiens] [Reaction:8849969] PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane [Homo sapiens]
(replacementInstances)	[_Deleted:8863125] Deletion of instance: 1676191 [_Deleted:8948124] Deletion of instance: 202371
(updatedInstance)	[_UpdateTracker:9782099] Update Tracker - [Reaction:199456] PTEN dephosphorylates PIP3 - v59:[addLiteratureReference, modifyText] [_UpdateTracker:9783014] Update Tracker - [Reaction:199456] PTEN dephosphorylates PIP3 - v57:[addLiteratureReference, modifyText] [_UpdateTracker:9788378] Update Tracker - [Reaction:199456] PTEN dephosphorylates PIP3 - v42:[modifyText]
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