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Details on Person THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation

Class:Id	Reaction:199443
_displayName	THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
_doRelease	TRUE
_timestamp	2017-07-28 14:53:14
authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:199435] Jassal, B, 2007-07-10 12:01:00
edited	[InstanceEdit:2426555] Matthews, L, 2012-08-03
goBiologicalProcess	[GO_BiologicalProcess:263612] negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
input	[DefinedSet:2400007] THEM4/TRIB3 [plasma membrane] [Homo sapiens] [Complex:2317329] AKT:PIP3 [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:199446] Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane [LiteratureReference:199452] TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver
modified	[InstanceEdit:202099] Jassal, B, 2007-10-18 12:39:52 [InstanceEdit:202683] Jassal, Bijay, 2007-11-08 [InstanceEdit:211298] Jassal, B, 2008-01-30 10:40:56 [InstanceEdit:215417] Jassal, B, 2008-02-28 15:14:23 [InstanceEdit:1262966] Jassal, B, 2011-05-06 [InstanceEdit:1273428] Jassal, B, 2011-05-11 [InstanceEdit:2400014] Orlic-Milacic, M, 2012-07-13 [InstanceEdit:2428913] Orlic-Milacic, M, 2012-08-08 [InstanceEdit:2457754] Orlic-Milacic, M, 2012-08-28 [InstanceEdit:2463861] Orlic-Milacic, M, 2012-08-30 [InstanceEdit:9014474] Orlic-Milacic, Marija, 2017-07-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
output	[Complex:199453] AKT:PIP3:THEM4/TRIB3 [plasma membrane] [Homo sapiens]
releaseDate	2008-03-12
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37 [InstanceEdit:2463860] Thorpe, Lauren, 2012-08-13 [InstanceEdit:2463859] Yuzugullu, Haluk, 2012-08-13 [InstanceEdit:2463854] Zhao, Jean J, 2012-08-13
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:2422427] Orlic-Milacic, M, 2012-07-18
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361187] R-HSA-199443.3
summation	[Summation:199427] The phosphorylation of membrane-recruited AKT at threonine a...
(hasEvent)	[Pathway:199418] Negative regulation of the PI3K/AKT network [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9788437] Update Tracker - [Reaction:199443] THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation - v42:[add_removeInput, modifyText] [_UpdateTracker:9789498] Update Tracker - [Reaction:199443] THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation - v38:[modifyText]
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