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Details on Person Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B

Class:Id	LiteratureReference:199317
_displayName	Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B
_timestamp	2007-07-10 08:10:44
author	[Person:199337] Scheid, MP [Person:199339] Marignani, PA [Person:166957] Woodgett, JR
created	[InstanceEdit:199370] Jassal, B, 2007-07-10 08:08:36
journal	Mol Cell Biol
pages	6247-60
pubMedIdentifier	12167717
title	Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B
volume	22
year	2002
(literatureReference)	[Reaction:198640] mTORC2 phosphorylates AKT at S473 [Homo sapiens] [Reaction:2317314] AKT binds PDPK1 [Homo sapiens] [Reaction:2317332] PIP3 recruits AKT to the membrane [Homo sapiens] [Reaction:9603279] PIP3 recruits PDK1 and AKT to the membrane [Homo sapiens] [Reaction:9980243] NICD1 positively regulates mTORC2-mediated phosphorylation of AKT at S473 [Homo sapiens] [Summation:198363] Once AKT is localized at the plasma membrane, it is phosphor... [Summation:202051] Under conditions of growth and mitogen stimulation S473 phos... [Summation:2326765] PIP3 generated by PI3K recruits AKT (also known as protein k... [Summation:2326766] Once phosphorylated on serine residue S473, AKT bound to PIP...
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