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Details on Person AKT phosphorylates FOXO transcription factors

Class:IdReaction:199299
_displayNameAKT phosphorylates FOXO transcription factors
_doReleaseTRUE
_timestamp2018-10-31 15:07:19
authored[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
catalystActivity[CatalystActivity:199274] protein serine/threonine kinase activity of p-T,p-S-AKT [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:199263] Jassal, B, 2007-07-10 07:58:55
edited[InstanceEdit:9627016] Orlic-Milacic, Marija, 2018-10-31
goBiologicalProcess[GO_BiologicalProcess:172430] phosphatidylinositol 3-kinase/protein kinase B signal transduction
input[CandidateSet:199272] FOXO1,FOXO3,FOXO4,(FOXO6) [nucleoplasm] [Homo sapiens]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
literatureReference[LiteratureReference:199294] Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B
[LiteratureReference:199277] Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
[LiteratureReference:9615009] FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics
[LiteratureReference:9615006] FoxO6 transcriptional activity is regulated by Thr26 and Ser184, independent of nucleo-cytoplasmic shuttling
modified[InstanceEdit:199866] Jassal, B, 2007-07-12 14:41:47
[InstanceEdit:202667] Jassal, B, 2007-11-08 15:44:30
[InstanceEdit:211152] D'Eustachio, P, 2008-01-28 22:58:31
[InstanceEdit:211298] Jassal, B, 2008-01-30 10:40:56
[InstanceEdit:215417] Jassal, B, 2008-02-28 15:14:23
[InstanceEdit:1262966] Jassal, B, 2011-05-06
[InstanceEdit:1273428] Jassal, B, 2011-05-11
[InstanceEdit:1534424] Orlic-Milacic, Marija, 2011-08-25
[InstanceEdit:9014477] Orlic-Milacic, Marija, 2017-07-28
[InstanceEdit:9614996] Orlic-Milacic, Marija, 2018-07-30
[InstanceEdit:9615012] Orlic-Milacic, Marija, 2018-07-30
[InstanceEdit:9623900] Orlic-Milacic, Marija, 2018-10-05
[InstanceEdit:9623908] Orlic-Milacic, Marija, 2018-10-05
[InstanceEdit:9625981] Orlic-Milacic, Marija, 2018-10-23
[InstanceEdit:9626977] Orlic-Milacic, Marija, 2018-10-30
[InstanceEdit:9626979] Orlic-Milacic, Marija, 2018-10-30
[InstanceEdit:9627017] Orlic-Milacic, Marija, 2018-10-31
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameAKT phosphorylates FOXO transcription factors
output[CandidateSet:9614997] p-T24,S256,S319-FOXO1,p-T32,S253,S315-FOXO3,p-T32,S197,S262-FOXO4,(p-T26,S184-FOXO6) [nucleoplasm] [Homo sapiens]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
precedingEvent
releaseDate2008-03-12
reviewed[InstanceEdit:9625979] Donlon, Timothy, 2018-10-17
[InstanceEdit:9626974] Bertaggia, Enrico, 2018-10-26
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358298] R-HSA-199299.5
summation[Summation:199308] AKT-mediated phosphorylation of Forkhead box (FOX) transcrip...
(hasEvent)[Pathway:198693] AKT phosphorylates targets in the nucleus [Homo sapiens]
[Pathway:9614399] Regulation of localization of FOXO transcription factors [Homo sapiens]
(normalReaction)[Reaction:2399992] AKT1 E17K mutant phosphorylates forkhead box transcription factors [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9614414] AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol [Homo sapiens]
(updatedInstance)[_UpdateTracker:9778932] Update Tracker - [Reaction:199299] AKT phosphorylates FOXO transcription factors - v67:[modifyText, removeLiteratureReference]
[_UpdateTracker:9779221] Update Tracker - [Reaction:199299] AKT phosphorylates FOXO transcription factors - v66:[addLiteratureReference, add_removeOutput, modifyText]
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