Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person PANK1/3 phosphorylate PanK

Class:IdReaction:199203
_displayNamePANK1/3 phosphorylate PanK
_doReleaseTRUE
_timestamp2023-07-26 14:30:21
authored[InstanceEdit:199189] D'Eustachio, P, 2007-07-09 22:03:12
catalystActivity[CatalystActivity:199185] pantothenate kinase activity of PANK1/3 [cytosol]
catalystActivityReference[CatalystActivityReference:9837291] pantothenate kinase activity of PANK1/3 [cytosol] Inherited Disorders of Coenzyme A Biosynthesis: Models, Mechanisms, and Treatments
compartment[Compartment:70101] cytosol
created[InstanceEdit:199189] D'Eustachio, P, 2007-07-09 22:03:12
input[SimpleEntity:196820] PanK [cytosol]
[SimpleEntity:113592] ATP [cytosol]
literatureReference[LiteratureReference:9837296] Inherited Disorders of Coenzyme A Biosynthesis: Models, Mechanisms, and Treatments
[LiteratureReference:196860] Coenzyme A: back in action
[LiteratureReference:199193] PPARalpha controls the intracellular coenzyme A concentration via regulation of PANK1alpha gene expression
[LiteratureReference:199198] The murine pantothenate kinase (Pank1) gene encodes two differentially regulated pantothenate kinase isozymes
[LiteratureReference:199209] A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome
modified[InstanceEdit:199241] D'Eustachio, P, 2007-07-09 22:09:46
[InstanceEdit:200987] Gopinathrao, G, 2007-07-27 15:28:23
[InstanceEdit:380254] D'Eustachio, P, 2008-11-11 13:23:39
[InstanceEdit:732460] D'Eustachio, P, 2010-05-12
[InstanceEdit:3150161] D'Eustachio, P, 2013-02-19
[InstanceEdit:3165246] Jassal, B, 2013-02-22
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9837287] D'Eustachio, Peter, 2023-06-12
[InstanceEdit:9840789] D'Eustachio, Peter, 2023-07-26
namePANK1/3 phosphorylate PanK
(R)-pantothenate + ATP => (R)-4'-phosphopantothenate + ADP + H(+)
Pantothenate is phosphorylated [PANK1;3;4]
output[SimpleEntity:196786] PPanK [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:70106] H+ [cytosol]
precedingEvent
previousReviewStatus[ReviewStatus:9821384] two stars
releaseDate2006-08-02
reviewed[InstanceEdit:9840788] Hill, David P, 2023-07-26
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359589] R-HSA-199203.4
structureModified[InstanceEdit:9837287] D'Eustachio, Peter, 2023-06-12
summation[Summation:199200] Cytosolic pantothenate kinases 1 and 3 (PANK1, PANK3) cataly...
(hasEvent)[Pathway:196783] Coenzyme A biosynthesis [Homo sapiens]
(precedingEvent)[Reaction:196753] 2xPPCS ligates PPanK with Cys [Homo sapiens]
[Reaction:8938300] Vanin hydrolyses pantetheine to PanK, 2AET [Homo sapiens]
(updatedInstance)[_UpdateTracker:9791674] Update Tracker - [Reaction:199203] PANK1/3/4 phosphorylate PanK - v27:[add_removeOutput]
[_UpdateTracker:9842354] Update Tracker - [Reaction:199203] PANK1/3 phosphorylate PanK - v86:[addLiteratureReference, addOutput, modifyText]
[Change default viewing format]
No pathways have been reviewed or authored by PANK1/3 phosphorylate PanK (199203)
Follow Reactome