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Details on Person Phosphopantetheine conjugation of the ACP domain of FAS

Class:Id	Reaction:199202
_displayName	Phosphopantetheine conjugation of the ACP domain of FAS
_doRelease	TRUE
_timestamp	2023-12-22 19:25:45
authored	[InstanceEdit:199189] D'Eustachio, P, 2007-07-09 22:03:12
catalystActivity	[CatalystActivity:199214] holo-[acyl-carrier-protein] synthase activity of AASDHPPT [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:199189] D'Eustachio, P, 2007-07-09 22:03:12
input	[SimpleEntity:76194] CoA-SH [cytosol] [EntityWithAccessionedSequence:199233] FASN [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:199204] Cloning, expression, and characterization of a human 4'-phosphopantetheinyl transferase with broad substrate specificity
modified	[InstanceEdit:199241] D'Eustachio, P, 2007-07-09 22:09:46 [InstanceEdit:200987] Gopinathrao, G, 2007-07-27 15:28:23 [InstanceEdit:732460] D'Eustachio, P, 2010-05-12 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9856745] D'Eustachio, Peter, 2023-12-22
name	Phosphopantetheine conjugation of the ACP domain of FAS CoA-SH + FAS apoenzyme => adenosine 3',5'-bisphosphate + FAS holoenzyme
output	[EntityWithAccessionedSequence:54659] FASN [cytosol] [Homo sapiens] [SimpleEntity:158466] PAP [cytosol]
precedingEvent	[Reaction:196773] COASY phosphorylates DP-CoA [Homo sapiens] [Reaction:196754] COASY transfers an adenylyl group from ATP to PPANT [Homo sapiens] [BlackBoxEvent:163733] Transcriptional activation of FASN monomer gene by ChREBP:MLX [Homo sapiens] [Reaction:9856546] MLXIPL:MLX binds FASN gene promoter [Homo sapiens]
releaseDate	2007-09-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360942] R-HSA-199202.4
summation	[Summation:199230] Cytosolic AASDHPPT (alpha-aminoadipic semialdehyde dehydroge...
(hasEvent)	[Pathway:199220] Vitamin B5 (pantothenate) metabolism [Homo sapiens]
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No pathways have been reviewed or authored by Phosphopantetheine conjugation of the ACP domain of FAS (199202)