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Details on Person Expression of CYP1A1

Class:Id	BlackBoxEvent:1989764
_displayName	Expression of CYP1A1
_doRelease	TRUE
_timestamp	2025-07-21 16:37:39
authored	[InstanceEdit:1989769] May, B, 2011-11-08
compartment	[Compartment:7660] nucleoplasm [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:1989763] May, B, 2011-11-13
edited	[InstanceEdit:1989769] May, B, 2011-11-08
goBiologicalProcess	[GO_BiologicalProcess:17788] positive regulation of transcription by RNA polymerase II
input	[EntityWithAccessionedSequence:5649956] CYP1A1 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:561142] Profiling of promoter occupancy by PPAR{alpha} in human hepatoma cells via ChIP-chip analysis [LiteratureReference:561153] Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human [LiteratureReference:8937160] Regulation of constitutive and inducible AHR signaling: complex interactions involving the AHR repressor [LiteratureReference:8937206] The aryl hydrocarbon receptor complex and the control of gene expression [LiteratureReference:8937186] The arylhydrocarbon receptor repressor (AhRR): structure, expression, and function
modified	[InstanceEdit:5649962] May, Bruce, 2014-11-24 [InstanceEdit:8937245] Jassal, Bijay, 2016-08-30 [InstanceEdit:8937246] Jassal, Bijay, 2016-08-30 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9626990] May, Bruce, 2018-10-31 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9961204] D'Eustachio, Peter, 2025-07-21
name	Expression of CYP1A1
output	[EntityWithAccessionedSequence:52623] CYP1A1 [endoplasmic reticulum membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:400143] Fatty acid ligands activate PPARA [Homo sapiens] [BlackBoxEvent:400183] PPARA:RXRA binds Corepressors of PPARA [Homo sapiens] [Reaction:2026996] FABP1 transports fatty acids into the nucleus [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:1989817] Positive gene expression regulation by 'PPARA:RXRA Coactivator complex [nucleoplasm]' [NegativeGeneExpressionRegulation:8937237] Negative gene expression regulation by 'AHRR:ARNT [nucleoplasm]' [PositiveGeneExpressionRegulation:8937241] Positive gene expression regulation by 'AHR:TCDD:ARNT [nucleoplasm]'
regulationReference	[RegulationReference:9642535] Positive gene expression regulation by 'PPARA:RXRA Coactivator complex [nucleoplasm]' Profiling of promoter occupancy by PPAR{alpha} in human hepatoma cells via ChIP-chip analysis
releaseDate	2011-12-06
reviewed	[InstanceEdit:425906] Kersten, S, 2009-06-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016645] R-HSA-1989764.7
summation	[Summation:1989636] The CYP1A1 gene is transcribed to yield mRNA and the mRNA is...
(hasEvent)	[Pathway:1989781] PPARA activates gene expression [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9782336] Update Tracker - [BlackBoxEvent:1989764] Expression of CYP1A1 - v59:[addLiteratureReference, addRegulator, modifyText] [_UpdateTracker:9785316] Update Tracker - [BlackBoxEvent:1989764] Expression of CYP1A1 - v52:[addInput]
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