Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person VCAM1 binds Integrin alpha4beta1

Class:Id	Reaction:198941
_displayName	VCAM1 binds Integrin alpha4beta1
_doRelease	TRUE
_timestamp	2020-06-02 13:59:22
authored	[InstanceEdit:198923] de Bono, B, 2007-07-08 12:58:15
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:198942] de Bono, B, 2007-07-08 13:30:13
input	[Complex:198201] ITGA4:ITGB1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:197834] VCAM1 [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:198943] Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8 A resolution. [LiteratureReference:198938] Inhibition of LFA-1/ICAM-1 and VLA-4/VCAM-1 as a therapeutic approach to inflammation and autoimmune diseases
modified	[InstanceEdit:199467] de Bono, B, 2007-07-10 14:39:17 [InstanceEdit:200817] de Bono, B, 2007-07-25 08:28:41 [InstanceEdit:201332] Gopinathrao, G, 2007-08-06 14:46:29 [InstanceEdit:201357] de Bono, B, 2007-08-06 20:12:13 [InstanceEdit:201372] de Bono, B, 2007-08-07 09:56:58 [InstanceEdit:4210796] Jupe, S, 2013-08-15 [InstanceEdit:6793342] Garapati, Phani Vijay, 2015-09-01 [InstanceEdit:9690529] Jassal, Bijay, 2020-06-02 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	VCAM1 binds Integrin alpha4beta1
output	[Complex:198199] integrin alpha4beta1:VCAM1 [plasma membrane] [Homo sapiens]
regulatedBy	[NegativeRegulation:9690528] Negative regulation by 'ITGA4:ITGB1:natalizumab [plasma membrane]'
regulationReference	[RegulationReference:9690530] Negative regulation by 'ITGA4:ITGB1:natalizumab [plasma membrane]' Anti-alpha4 integrin therapy for multiple sclerosis: mechanisms and rationale
releaseDate	2007-08-21
reviewed	[InstanceEdit:201344] Trowsdale, J, 2007-08-06 [InstanceEdit:5692843] Barrow, Alexander D, 2015-05-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358618] R-HSA-198941.4
summation	[Summation:199468] Integrins play a central role in mediating lymphocyte adhesi...
(hasEvent)	[Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell [Homo sapiens] [Pathway:216083] Integrin cell surface interactions [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776797] Update Tracker - [Reaction:198941] VCAM1 binds Integrin alpha4beta1 - v74:[addRegulator] [_UpdateTracker:9783536] Update Tracker - [Reaction:198941] VCAM1 binds Integrin alpha4beta1 - v56:[modifyText]
[Change default viewing format]

No pathways have been reviewed or authored by VCAM1 binds Integrin alpha4beta1 (198941)