Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person ERK1/2 phosphorylates MSK1

Class:IdReaction:198756
_displayNameERK1/2 phosphorylates MSK1
_doReleaseTRUE
_timestamp2024-03-18 20:06:18
authored[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
catalystActivity[CatalystActivity:198713] protein serine/threonine kinase activity of p-T,Y MAPK dimers [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:198764] 2007-07-10 08:01:57
input[EntityWithAccessionedSequence:198657] RPS6KA5 [nucleoplasm] [Homo sapiens]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
literatureReference[LiteratureReference:199367] Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB
modified[InstanceEdit:199259] Jassal, B, 2007-07-10 07:58:41
[InstanceEdit:199370] Jassal, B, 2007-07-10 08:08:36
[InstanceEdit:202683] Jassal, Bijay, 2007-11-08
[InstanceEdit:211298] Jassal, B, 2008-01-30 10:40:56
[InstanceEdit:215417] Jassal, B, 2008-02-28 15:14:23
[InstanceEdit:6798228] Rothfels, Karen, 2015-09-17
[InstanceEdit:9009211] Orlic-Milacic, Marija, 2017-06-15
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9865777] Orlic-Milacic, Marija, 2024-03-18
nameERK1/2 phosphorylates MSK1
output[EntityWithAccessionedSequence:198683] p-S212,S360,S376,T581-RPS6KA5 [nucleoplasm] [Homo sapiens]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
precedingEvent
releaseDate2008-03-12
reviewed[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359692] R-HSA-198756.5
summation[Summation:202693] MSK1 (Ribosomal protein S6 kinase alpha-5) is a serine/threo...
(hasEvent)[Pathway:198753] ERK/MAPK targets [Homo sapiens]
[Pathway:375165] NCAM signaling for neurite out-growth [Homo sapiens]
(precedingEvent)[Reaction:199910] MSK1 activates ATF1 [Homo sapiens]
[Reaction:199935] MSK1 activates CREB [Homo sapiens]
(updatedInstance)[_UpdateTracker:9780540] Update Tracker - [Reaction:198756] ERK1/2 phosphorylates MSK1 - v62:[add_removeCatalystActivity]
[Change default viewing format]
No pathways have been reviewed or authored by ERK1/2 phosphorylates MSK1 (198756)