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Details on Person ERK1/2/5 activate RSK1/2/3

Class:Id	Reaction:198746
_displayName	ERK1/2/5 activate RSK1/2/3
_doRelease	TRUE
_timestamp	2024-03-18 20:06:20
authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
catalystActivity	[CatalystActivity:199864] protein serine/threonine kinase activity of p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:198764] 2007-07-10 08:01:57
edited	[InstanceEdit:3901124] D'Eustachio, P, 2013-07-15 [InstanceEdit:4542306] Matthews, L, 2013-07-15
input	[DefinedSet:199858] Ribosomal protein S6 kinase [nucleoplasm] [Homo sapiens] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm]
literatureReference	[LiteratureReference:199940] The MAP kinase ERK5 binds to and phosphorylates p90 RSK [LiteratureReference:444269] Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity
modified	[InstanceEdit:199866] Jassal, B, 2007-07-12 14:41:47 [InstanceEdit:199916] Jassal, B, 2007-07-13 13:44:04 [InstanceEdit:202683] Jassal, Bijay, 2007-11-08 [InstanceEdit:211298] Jassal, B, 2008-01-30 10:40:56 [InstanceEdit:215417] Jassal, B, 2008-02-28 15:14:23 [InstanceEdit:4415004] Orlic-Milacic, M, 2013-08-23 [InstanceEdit:4542310] Orlic-Milacic, M, 2013-09-04 [InstanceEdit:6798226] Rothfels, Karen, 2015-09-17 [InstanceEdit:9619830] Orlic-Milacic, Marija, 2018-09-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9865777] Orlic-Milacic, Marija, 2024-03-18
name	ERK1/2/5 activate RSK1/2/3
output	[DefinedSet:199849] Phospho-Ribosomal protein S6 kinase [nucleoplasm] [Homo sapiens] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm]
precedingEvent	[Reaction:198714] ERK5 translocates to the nucleus [Homo sapiens] [Reaction:198733] ERK5 is activated [Homo sapiens] [BlackBoxEvent:5674387] Phosphorylated MAPKs translocate into the nucleus [Homo sapiens] [Reaction:5674385] p-T,Y MAPKs dimerize [Homo sapiens] [BlackBoxEvent:9610166] p-T,Y MAPK dimers translocate to nucleus [Homo sapiens] [Reaction:5674385] p-T,Y MAPKs dimerize [Homo sapiens]
releaseDate	2008-03-12
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358820] R-HSA-198746.5
summation	[Summation:199918] The p90 ribosomal S6 kinases (RSK1-4) comprise a family of s...
(hasEvent)	[Pathway:198753] ERK/MAPK targets [Homo sapiens] [Pathway:881907] Gastrin-CREB signalling pathway via PKC and MAPK [Homo sapiens] [Pathway:2559582] Senescence-Associated Secretory Phenotype (SASP) [Homo sapiens]
(precedingEvent)	[Reaction:199895] RSK1/2/3 phosphorylates CREB at Serine 119 [Homo sapiens] [Reaction:3857328] RPS6KA1/2/3 phosphorylates CEBPB on S321 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9778945] Update Tracker - [Reaction:198746] ERK1/2/5 activate RSK1/2/3 - v67:[addLiteratureReference]
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No pathways have been reviewed or authored by ERK1/2/5 activate RSK1/2/3 (198746)