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Details on Person ERK1/2 activates ELK1

Class:Id	Reaction:198731
_displayName	ERK1/2 activates ELK1
_doRelease	TRUE
_timestamp	2024-03-18 20:06:16
authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
catalystActivity	[CatalystActivity:198713] protein serine/threonine kinase activity of p-T,Y MAPK dimers [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:198764] 2007-07-10 08:01:57
inferredFrom	[Reaction:198706] ERK1/2 activates ELK1 [Mus musculus]
input	[EntityWithAccessionedSequence:3009346] ELK1 [nucleoplasm] [Homo sapiens] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm]
literatureReference	[LiteratureReference:9625301] The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain [LiteratureReference:199346] ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation [LiteratureReference:9625249] Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1 [LiteratureReference:9625265] Journey to the surface of the cell: Fos regulation and the SRE
modified	[InstanceEdit:202683] Jassal, Bijay, 2007-11-08 [InstanceEdit:204310] Jassal, B, 2007-11-28 10:59:29 [InstanceEdit:211298] Jassal, B, 2008-01-30 10:40:56 [InstanceEdit:215417] Jassal, B, 2008-02-28 15:14:23 [InstanceEdit:3009345] Jupe, S, 2013-02-05 [InstanceEdit:6798227] Rothfels, Karen, 2015-09-17 [InstanceEdit:9625459] Rothfels, Karen, 2018-10-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9865777] Orlic-Milacic, Marija, 2024-03-18
name	ERK1/2 activates ELK1
output	[EntityWithAccessionedSequence:3009350] p-4S,T336-ELK1 [nucleoplasm] [Homo sapiens] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm]
precedingEvent	[BlackBoxEvent:5674387] Phosphorylated MAPKs translocate into the nucleus [Homo sapiens] [Reaction:5674385] p-T,Y MAPKs dimerize [Homo sapiens] [BlackBoxEvent:9610166] p-T,Y MAPK dimers translocate to nucleus [Homo sapiens] [Reaction:5674385] p-T,Y MAPKs dimerize [Homo sapiens]
releaseDate	2008-03-12
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361845] R-HSA-198731.5
summation	[Summation:198707] Following translocation to the nucleus, ERK1/2 directly phos...
(hasEvent)	[Pathway:198753] ERK/MAPK targets [Homo sapiens] [Pathway:9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling [Homo sapiens]
(precedingEvent)	[Reaction:9625479] SRF and ELK1 bind the FOS gene [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9778069] Update Tracker - [Reaction:198731] ERK1/2 activates ELK1 - v68:[modifyText] [_UpdateTracker:9778900] Update Tracker - [Reaction:198731] ERK1/2 activates ELK1 - v67:[addLiteratureReference, modifyText] [_UpdateTracker:9787807] Update Tracker - [Reaction:198731] ERK1/2 activates ELK1 - v44:[add_removeInput, add_removeOutput]
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