Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Following translocation to the nucleus, ERK1/2 directly phos...
| Class:Id | Summation:198707 |
|---|---|
| _displayName | Following translocation to the nucleus, ERK1/2 directly phos... |
| _timestamp | 2019-01-11 22:19:14 |
| created | [InstanceEdit:198764] 2007-07-10 08:01:57 |
| modified | [InstanceEdit:202683] Jassal, Bijay, 2007-11-08 [InstanceEdit:9625457] Rothfels, Karen, 2018-10-19 [InstanceEdit:9634617] Rothfels, Karen, 2019-01-11 |
| text | Following translocation to the nucleus, ERK1/2 directly phosphorylates key effectors, including the ubiquitous transcription factors ELK1 (Ets like protein 1). At least five residues in the C terminal domain of ELK1 are phosphorylated upon stimulation with growth factor stimulation. ELK1 can form a ternary complex with the serum response factor (SRF) and consensus sequences, such as serum response elements (SRE), on DNA, thus stimulating transcription of a set of immediate early genes like FOS (c-fos) (Marais et al, 1993; Gille et al, 1995; Duan et al, 1998; reviewed in Treisman, 1995). |
| (summation) | [Reaction:198706] ERK1/2 activates ELK1 [Mus musculus] [Reaction:198731] ERK1/2 activates ELK1 [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by Following translocation to the nucleus, ERK1/2 directly phos... (198707)
