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Details on Person MDM2 [cytosol]

Class:Id	EntityWithAccessionedSequence:198644
_displayName	MDM2 [cytosol]
_timestamp	2012-07-13 14:43:39
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:198616] Jassal, B, 2007-06-29 07:57:48
endCoordinate	491
modified	[InstanceEdit:2399978] Orlic-Milacic, M, 2012-07-13
name	MDM2 Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2) Ubiquitin-protein ligase E3 Mdm2 p53-binding protein Mdm2 Oncoprotein Mdm2 Double minute 2 protein Hdm2
referenceEntity	[ReferenceGeneProduct:95018] UniProt:Q00987 MDM2 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:370361] R-HSA-198644.1
startCoordinate	1
(activeUnit)	[CatalystActivity:9934662] ubiquitin-protein transferase activity of CDH1:MDM2 [plasma membrane]
(hasComponent)	[Complex:9934664] PolyUbK48-CDH1:MDM2 [plasma membrane] [Homo sapiens] [Complex:9934665] CDH1:MDM2 [plasma membrane] [Homo sapiens] [Complex:9934666] PolyUbK48-CDH1:MDM2 [early endosome membrane] [Homo sapiens]
(input)	[Reaction:198599] AKT phosphorylates MDM2 [Homo sapiens] [Reaction:2399981] AKT1 E17K mutant phosphorylates MDM2 [Homo sapiens] [Reaction:6795460] SGK1 phosphorylates MDM2 [Homo sapiens] [BlackBoxEvent:9766219] MDM2 binds CDH1 [Homo sapiens] [BlackBoxEvent:9851102] NPM1-ALK- and PI3K-dependent MDM2 phosphorylation [Homo sapiens]
(output)	[Reaction:6795667] MDM2 translocates to the cytosol [Homo sapiens] [BlackBoxEvent:9766223] Proteasome-dependent degradation of ubiquitinated CDH1 [Homo sapiens] [BlackBoxEvent:9768925] MDM2 gene expression is repressed by NPAS4 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9873318] Update Tracker - [EntityWithAccessionedSequence:198644] MDM2 [cytosol] - v42:[modifyEndCoordinate]
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No pathways have been reviewed or authored by MDM2 [cytosol] (198644)